(Q41915822)

English

Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?

scientific article published on May 2003

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

14 October 2017

Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease? (English)

1 reference

Europe PubMed Central

14 October 2017

Alzheimer's disease

0 references

author name string

Jennifer Bendiske

1

1 reference

Europe PubMed Central

14 October 2017

Ben A Bahr

2

1 reference

Europe PubMed Central

14 October 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 May 2003

1 reference

Europe PubMed Central

14 October 2017

Journal of Neuropathology & Experimental Neurology

1 reference

Europe PubMed Central

14 October 2017

62

1 reference

Europe PubMed Central

14 October 2017

5

1 reference

Europe PubMed Central

14 October 2017

451-463

1 reference

Europe PubMed Central

14 October 2017

The neuropathogenic contributions of lysosomal dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Induction of beta-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Intracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Huntingtin localization in brains of normal and Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Beta-nerve growth factor measurements in mouse serum

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Beta-amyloid increases cathepsin D levels in hippocampus

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Regional synaptic pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Alzheimer's disease and Abeta toxicity: from top to bottom

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Alzheimer's disease is a synaptic failure

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Progressive reduction of synaptophysin message in single neurons in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Survival signaling and selective neuroprotection through glutamatergic transmission

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Excitatory amino acid AMPA receptor mRNA localization in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer's disease and Lewy body variant

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Reduction of AMPA-selective glutamate receptor subunits in the entorhinal cortex of patients with Alzheimer's disease pathology: a biochemical study.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Distinct distributions of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits and a related 53,000 M(R) antigen (GR53) in brain tissue.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

The up-regulation of endosomal-lysosomal components in amyloid beta-resistant cells

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: an in situ hybridization study.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Modulation of A(beta) peptides by estrogen in mouse models

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Alzheimer's disease in man and transgenic mice: females at higher risk

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Age-related phosphorylation and fragmentation events influence the distribution profiles of distinct tau isoforms in mouse brain.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Miniature synaptic events maintain dendritic spines via AMPA receptor activation.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.5.451

21 January 2018

Identifiers

10.1093/JNEN/62.5.451

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41915822&oldid=1633598108"