(Q41917203)

14 October 2017

Intracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline (English)

1 reference

14 October 2017

Jennifer Bendiske

1

1 reference

14 October 2017

Ebru Caba

series ordinal

2

1 reference

14 October 2017

Queenie B Brown

series ordinal

3

1 reference

14 October 2017

Ben A Bahr

series ordinal

4

1 reference

14 October 2017

1 July 2002

1 reference

Journal of Neuropathology & Experimental Neurology

14 October 2017

1 reference

14 October 2017

61

1 reference

14 October 2017

640-650

1 reference

14 October 2017

7

1 reference

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

14 October 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Induction of beta-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Neurofibrillary tangles of paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Synaptophysin gene expression in human brain: a quantitative in situ hybridization and immunocytochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Synaptic pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Distinct distributions of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits and a related 53,000 M(R) antigen (GR53) in brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Specific proteolysis of the NR2 subunit at multiple sites by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Changes in the concentrations of tau and other structural proteins in the brains of aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Regional synaptic pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Axonal transport in neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Tau domains, phosphorylation, and interactions with microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Glutamate(NMDA) receptor NR1 subunit mRNA expression in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

The neuropathogenic contributions of lysosomal dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Peptidyl alpha-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Survival signaling and selective neuroprotection through glutamatergic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F61.7.640

21 January 2018

Identifiers

DOI

10.1093/JNEN/61.7.640

1 reference

14 October 2017

1 reference