(Q46691166)

24 December 2017

title

Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site (English)

1 reference

24 December 2017

author

Sunghyun Kang

1

1 reference

24 December 2017

Anjana Rao

3

object named as

Anjana Rao

1 reference

24 December 2017

author name string

Huiming Li

2

1 reference

24 December 2017

Patrick G Hogan

4

1 reference

24 December 2017

language of work or name

English

0 references

publication date

7 September 2005

1 reference

24 December 2017

Journal of Biological Chemistry

published in

1 reference

24 December 2017

volume

280

1 reference

24 December 2017

issue

45

1 reference

24 December 2017

page(s)

37698-37706

1 reference

24 December 2017

Transcription factors of the NFAT family: regulation and function

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

The role of NF-AT transcription factors in T cell activation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

NFAT signaling: choreographing the social lives of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Transcriptional regulation by calcium, calcineurin, and NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Defective T cell development and function in calcineurin A beta -deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Isolation of mutant T lymphocytes with defects in capacitative calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Nuclear factor of activated T cells contains Fos and Jun.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Superoxide dismutase protects calcineurin from inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Sensing electrons: protein phosphatase redox regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Redox control of calcineurin by targeting the binuclear Fe(2+)-Zn(2+) center at the enzyme active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Differential susceptibilities of serine/threonine phosphatases to oxidative and nitrosative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Measurement of Calcineurin Phosphatase Activity in Cell Extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Structure of a quinohemoprotein amine dehydrogenase with an uncommon redox cofactor and highly unusual crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine Clara cells after exposure to naphthalene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Tethering: fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Covalent modification as a strategy to block protein-protein interactions with small-molecule drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Is calcineurin a peroxide-specific sensor in T-lymphocytes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

Calcineurin regulates induction of late phase of cerebellar long-term depression in rat cultured Purkinje neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502247200

21 January 2018

Identifiers

DOI

10.1074/JBC.M502247200

1 reference

24 December 2017

1 reference

24 December 2017