(Q46703082)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16162505%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding (English)

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6 January 2020

8

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6 January 2020

Mark John Ingraham Paine

2

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6 January 2020

Jean-Didier Maréchal

4

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6 January 2020

Mike Sutcliffe

7

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6 January 2020

9

C Roland Wolf

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6 January 2020

3

Carol A Kemp

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6 January 2020

1

Lesley A McLaughlin

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6 January 2020

author name string

Jack U Flanagan

5

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6 January 2020

Clive J Ward

6

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6 January 2020

language of work or name

English

0 references

publication date

14 September 2005

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Journal of Biological Chemistry

6 January 2020

published in

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6 January 2020

volume

280

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6 January 2020

issue

46

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6 January 2020

page(s)

38617-38624

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Polymorphic hydroxylation of Debrisoquine in man.

6 January 2020

cites work

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Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

21 January 2018

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Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.

21 January 2018

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Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.

21 January 2018

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Substrate interaction with cytochrome P-450.

21 January 2018

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Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

21 January 2018

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Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues

21 January 2018

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Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

21 January 2018

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Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

21 January 2018

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Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

21 January 2018

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Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

21 January 2018

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Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

21 January 2018

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Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

21 January 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

1 reference

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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

21 January 2018

1 reference

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

High-resolution crystal structure of cytochrome P450cam

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

21 January 2018

1 reference

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

21 January 2018

1 reference

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Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

21 January 2018

1 reference

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Improved protein-ligand docking using GOLD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505974200

21 January 2018

Identifiers

DOI

10.1074/JBC.M505974200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16162505%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference