(Q46718140)

24 December 2017

title

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V. (English)

1 reference

24 December 2017

4

Magdeleine Hung

1 reference

24 December 2017

author name string

John K Ly

1

1 reference

24 December 2017

Nicolas A Margot

2

1 reference

24 December 2017

Holly L MacArthur

3

1 reference

24 December 2017

Michael D Miller

5

1 reference

24 December 2017

Kirsten L White

6

1 reference

24 December 2017

publication date

1 January 2007

1 reference

24 December 2017

Antiviral Chemistry & Chemotherapy

published in

1 reference

24 December 2017

volume

18

1 reference

24 December 2017

issue

6

1 reference

24 December 2017

page(s)

307-316

1 reference

24 December 2017

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

cites work

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

A novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Early virologic failure and rescue therapy of tenofovir, abacavir, and lamivudine for initial treatment of HIV-1 infection: TONUS study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Effect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Physiological concentrations of purines and pyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020701800603

10.1177/095632020701800603

21 January 2018

Identifiers

DOI

1 reference

24 December 2017

1 reference

24 December 2017