(Q46750400)

24 December 2017

title

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function (English)

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24 December 2017

main subject

Drosophila melanogaster

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Sarah Dmel_CG6072

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GOA release 2020-03-11

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Kyung-Tai Min

2

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author name string

Karen T Chang

series ordinal

1

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24 December 2017

language of work or name

English

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publication date

16 October 2005

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24 December 2017

published in

Nature Neuroscience

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24 December 2017

volume

8

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24 December 2017

issue

11

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24 December 2017

page(s)

1577-1585

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24 December 2017

https://scigraph.springernature.com/pub.10.1038/nn1564

exact match

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cites work

Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders

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7 January 2021

Mitochondria, oxidants, and aging

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7 January 2021

Mitochondrial diseases in man and mouse

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7 January 2021

Mitochondrial dysfunction and Down's syndrome.

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7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

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Mitochondrial disorders

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Mitochondrial enzyme deficiencies in Down's syndrome

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7 January 2021

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

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7 January 2021

Evidence for increased mitochondrial superoxide production in Down syndrome.

1 reference

7 January 2021

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

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7 January 2021

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

1 reference

7 January 2021

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

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7 January 2021

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

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7 January 2021

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

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7 January 2021

The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress.

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7 January 2021

Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress.

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7 January 2021

adapt78 protects cells against stress damage and suppresses cell growth

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7 January 2021

Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons.

1 reference

7 January 2021

Mutational analyses of the signals involved in the subcellular location of DSCR1.

1 reference

7 January 2021

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

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7 January 2021

Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.

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7 January 2021

GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

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7 January 2021

Multiple domains of MCIP1 contribute to inhibition of calcineurin activity

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7 January 2021

The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.

1 reference

7 January 2021

Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila

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7 January 2021

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

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7 January 2021

Mitochondrial disease in mouse results in increased oxidative stress

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7 January 2021

Role of adenine nucleotide translocator 1 in mtDNA maintenance

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7 January 2021

The eyes of mito-mouse: mouse models of mitochondrial disease

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7 January 2021

Mouse models for mitochondrial disease

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7 January 2021

Topology of superoxide production from different sites in the mitochondrial electron transport chain

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7 January 2021

A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)

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7 January 2021

Azurophilic granules in acute lymphoblastic leukaemia resulting from abundant mitochondria.

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7 January 2021

Mitochondrial abnormalities in Alzheimer's disease.

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7 January 2021

Cytochrome oxidase in Alzheimer's disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems.

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7 January 2021

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7 January 2021

Down syndrome, Alzheimer's disease and seizures

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7 January 2021

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

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7 January 2021

The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila

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7 January 2021

Immunochemistry on ultrathin frozen sections

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7 January 2021

Dissociated neurons from normal and mutant Drosophila larval central nervous system in cell culture

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7 January 2021

Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion

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7 January 2021

Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing

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7 January 2021

Identifiers

DOI

10.1038/NN1564

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24 December 2017

PubMed ID

16222229

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24 December 2017