(Q46772992)

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A role for p53 in the regulation of lysosomal permeability by delta 9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration

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scholarly article

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

A role for p53 in the regulation of lysosomal permeability by delta 9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration (English)

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

tetrahydrocannabinol

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author name string

Aoife Gowran

1

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

Veronica A Campbell

2

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

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4 February 2008

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

Journal of Neurochemistry

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

105

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

1513-1524

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

4

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

The effects of cannabinoids on the brain

1 reference

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Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture

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The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.

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Pathological apoptosis in the developing brain

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Lysosomal involvement in apoptosis

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21 January 2018

Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation

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Alzheimer's disease; taking the edge off with cannabinoids?

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Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

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Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy

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Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells

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Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor.

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Tetrahydrocannabinol‐induced neurotoxicity depends on CB1 receptor‐mediated c‐Jun N‐terminal kinase activation in cultured cortical neurons

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A comparison of the apoptotic effect of Delta(9)-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex

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The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta9-tetrahydrocannabinol in cultured cortical neurons.

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Endocannabinoids in the central nervous system: from neuronal networks to behavior

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A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function

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Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

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Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development

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Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity.

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p53 and metabolism: Inside the TIGAR.

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Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants

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The emerging functions of endocannabinoid signaling during CNS development.

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21 January 2018

Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function.

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Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).

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Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.

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21 January 2018

Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine

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Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium

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Lysosomal membrane permeabilization during apoptosis--involvement of Bax?

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

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Role of oxygen free radicals and pH on the release of cardiac lysosomal enzymes.

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Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2.

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Induction of cell death by the lysosomotropic detergent MSDH.

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Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

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Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis

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The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells

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Triggering caspase-independent cell death to combat cancer.

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Altered brain tissue composition in heavy marijuana users

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Delta(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages

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Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review

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Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.

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Cellular injury induced by oxidative stress is mediated through lysosomal damage.

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Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

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The acute effects of cannabinoids on memory in humans: a review

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Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage

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Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol

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Neurotoxicology of cannabis and THC: A review of chronic exposure studies in animals

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

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Lysosomal cysteine cathepsins: signaling pathways in apoptosis

1 reference

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Apoptotic pathways: involvement of lysosomal proteases

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Lack of hippocampal volume change in long-term heavy cannabis users

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Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

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Hypothesis: cannabinoid therapy for the treatment of gliomas?

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Lysosomal destabilization in p53-induced apoptosis

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Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells

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Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis

1 reference

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The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells

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Identifiers

10.1111/J.1471-4159.2008.05278.X

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18248609

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