(Q46776548)

25 December 2017

title

Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons (English)

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25 December 2017

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25 December 2017

Paul J Hertzog

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25 December 2017

author name string

K Cimdins

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25 December 2017

U Ali

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25 December 2017

R C Iannello

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25 December 2017

publication date

27 October 2005

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25 December 2017

Journal of Neural Transmission

published in

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25 December 2017

volume

113

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25 December 2017

issue

5

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25 December 2017

page(s)

645-657

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25 December 2017

The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00702-005-0352-Y

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

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12 December 2020

Vitamin E protects nerve cells from amyloid beta protein toxicity

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12 December 2020

Is apoptosis key in Alzheimer's disease?

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12 December 2020

The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.

1 reference

12 December 2020

Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: A model for tongue pathology in Down's syndrome

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12 December 2020

Metabolism and functions of glutathione in brain.

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12 December 2020

Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity

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12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

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12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.

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12 December 2020

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment

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12 December 2020

Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions

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12 December 2020

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

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12 December 2020

Antioxidant defence mechanisms: from the beginning to the end (of the beginning).

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12 December 2020

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

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12 December 2020

Impact of oxidative stress on neuronal survival.

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12 December 2020

Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

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12 December 2020

Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury.

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12 December 2020

The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome

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12 December 2020

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine

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12 December 2020

Alzheimer's disease: the two-hit hypothesis

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

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12 December 2020

Oxidative stress and neural dysfunction in Down syndrome.

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12 December 2020

Protein aggregation and neurodegenerative disease

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12 December 2020

Mitochondrial dysfunction in neurodegenerative diseases

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12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

12 December 2020

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12 December 2020

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

1 reference

12 December 2020

Changes of p53 in the brains of patients with Alzheimer's disease

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12 December 2020

What is the dominant Abeta species in human brain tissue? A review

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12 December 2020

The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides

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12 December 2020

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

1 reference

12 December 2020

Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death

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12 December 2020

Differential distribution of presenilin-1, Bax, and Bcl-X(L) in Alzheimer's disease and frontotemporal dementia

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12 December 2020

Metals in our minds: therapeutic implications for neurodegenerative disorders

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12 December 2020

Mechanisms of neurodegenerative disorders: Part 2: control of cell death.

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12 December 2020

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites

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12 December 2020

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.

1 reference

12 December 2020

A conformation change in the carboxyl terminus of Alzheimer's Abeta (1-40) accompanies the transition from dimer to fibril as revealed by fluorescence quenching analysis

1 reference

12 December 2020

Apoptosis in the nervous system

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12 December 2020

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12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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12 December 2020

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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12 December 2020

[40] Mitochondria, nitric oxide, and peroxynitrite

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12 December 2020

10.1007/S00702-005-0352-Y

Identifiers

DOI

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25 December 2017

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25 December 2017