(Q34400646)

1 August 2017

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title

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment (English)

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1 August 2017

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Halliwell B

1

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1 August 2017

1 January 2001

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1 August 2017

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1 August 2017

18

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1 August 2017

9

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1 August 2017

685-716

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https://scigraph.springernature.com/pub.10.2165/00002512-200118090-00004

1 August 2017

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cites work

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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence

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Antioxidants, oxidative stress, and degenerative neurological disorders

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12 December 2020

Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.

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12 December 2020

Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells

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12 December 2020

The isoprostanes: unique bioactive products of lipid peroxidation

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12 December 2020

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells

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12 December 2020

Degradation of oxidized proteins in mammalian cells.

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12 December 2020

Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy

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12 December 2020

Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease

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12 December 2020

Riluzole prolongs survival and delays muscle strength deterioration in mice with progressive motor neuronopathy (pmn)

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12 December 2020

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

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12 December 2020

Down's syndrome: a pathology involving the lack of balance of reactive oxygen species

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12 December 2020

Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

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12 December 2020

Assay using brain homogenate for measuring the antioxidant activity of biological fluids.

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12 December 2020

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.

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12 December 2020

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men.

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12 December 2020

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

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12 December 2020

Model for transport in the central nervous system

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12 December 2020

Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation.

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12 December 2020

Redox regulation of cellular activation

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12 December 2020

Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron.

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12 December 2020

Oxidative stress and motor neurone disease

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12 December 2020

Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?

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12 December 2020

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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12 December 2020

Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity

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12 December 2020

Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy).

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12 December 2020

Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo

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12 December 2020

Molecular actions of ebselen--an antiinflammatory antioxidant

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12 December 2020

4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease.

1 reference

12 December 2020

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

1 reference

12 December 2020

Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease

1 reference

12 December 2020

Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.

1 reference

12 December 2020

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

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12 December 2020

Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse.

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12 December 2020

Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice

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12 December 2020

Increased lipid peroxidation in the brains of aceruloplasminemia patients

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12 December 2020

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

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12 December 2020

Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls

1 reference

12 December 2020

The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease.

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12 December 2020

Non-caeruloplasmin copper and ferroxidase activity in mammalian serum. Ferroxidase activity and phenanthroline-detectable copper in human serum in Wilson's disease

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12 December 2020

Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.

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12 December 2020

The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases

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12 December 2020

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

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12 December 2020

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.

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12 December 2020

Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging--smoking enhances oxidative stress on the aged tissues

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12 December 2020

Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain.

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12 December 2020

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

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12 December 2020

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease

1 reference

12 December 2020

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

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12 December 2020

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12 December 2020

Recent developments in the drug treatment of Alzheimer's disease

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12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

12 December 2020

Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells.

1 reference

12 December 2020

Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals.

1 reference

12 December 2020

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

12 December 2020

The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli

1 reference

12 December 2020

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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12 December 2020

Neuroprotection by the metabolic antioxidant alpha-lipoic acid

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12 December 2020

Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants.

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12 December 2020

Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia

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12 December 2020

The cellular labile iron pool and intracellular ferritin in K562 cells

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12 December 2020

Impaired proteasome function in Alzheimer's disease

1 reference

12 December 2020

Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.

1 reference

12 December 2020

Prostaglandins as putative neurotoxins in Alzheimer's disease.

1 reference

12 December 2020

Economic analysis of tirilazad mesylate for aneurysmal subarachnoid hemorrhage. Economic evaluation of a phase III clinical trial in Europe and Australia

1 reference

12 December 2020

Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones

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12 December 2020

Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course

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12 December 2020

Protein oxidation in response to increased transcriptional or translational errors

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12 December 2020

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Antioxidant defence mechanisms: from the beginning to the end (of the beginning).

1 reference

12 December 2020

Tissue-specific functions of individual glutathione peroxidases

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12 December 2020

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders

1 reference

12 December 2020

Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK.

1 reference

12 December 2020

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

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12 December 2020

Mitochondrial disease in superoxide dismutase 2 mutant mice

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12 December 2020

Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation.

1 reference

12 December 2020

Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders

1 reference

12 December 2020

Dynamics of the cytosolic chelatable iron pool of K562 cells

1 reference

12 December 2020

Stability of mutant superoxide dismutase-1 associated with familial amyotrophic lateral sclerosis determines the manner of copper release and induction of thioredoxin in erythrocytes

1 reference

12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

12 December 2020

Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2'-deoxyguanosine in organs of Fischer 344 rats during aging

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12 December 2020

Role of nitric oxide in the control of mitochondrial function.

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12 December 2020

Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.

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12 December 2020

Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse

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12 December 2020

Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice.

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12 December 2020

Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease

1 reference

12 December 2020

Release of copper ions from the familial amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutants

1 reference

12 December 2020

A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group

1 reference

12 December 2020

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

1 reference

12 December 2020

Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.

1 reference

12 December 2020

Cerebrospinal fluid nitric oxide levels in childhood bacterial meningitis

1 reference

12 December 2020

Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group

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12 December 2020

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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12 December 2020

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

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12 December 2020

Regulation of the synthesis of brain metallothioneins.

1 reference

12 December 2020

Exposure of striatal [corrected] synaptosomes to L-dopa increases levels of oxidized glutathione.

1 reference

12 December 2020

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study

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12 December 2020

Evaluation of the antioxidant activity of melatonin in vitro

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12 December 2020

α-tocopherol concentrations of the nervous system and selected tissues of adult dogs fed three levels of vitamin E

1 reference

12 December 2020

The role of nitric oxide in neurodegeneration. Potential for pharmacological intervention

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12 December 2020

Hydrogen peroxide production by rat brain in vivo

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12 December 2020

The use of transgenic and mutant mice to study oxygen free radical metabolism

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12 December 2020

Drug antioxidant effects. A basis for drug selection?

1 reference

12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats

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12 December 2020

Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species

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12 December 2020

Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.

1 reference

12 December 2020

Neuroprotective effects of the novel brain-penetrating antioxidant U-101033E and the spin-trapping agent alpha-phenyl-N-tert-butyl nitrone (PBN)

1 reference

12 December 2020

The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity.

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12 December 2020

The antioxidant and biological properties of the carotenoids

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12 December 2020

Role of coenzyme Q and superoxide in vitamin E cycling

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12 December 2020

Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1 reference

12 December 2020

Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial.

1 reference

12 December 2020

Chemical determination of oxidative DNA damage by gas chromatography-mass spectrometry

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12 December 2020

Neurotoxicity of cysteine: interaction with glutamate

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12 December 2020

Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.

1 reference

12 December 2020

The suppression of iron release from activated myoglobin by physiological electron donors and by desferrioxamine

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12 December 2020

The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients

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12 December 2020

Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein

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12 December 2020

Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate

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12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

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12 December 2020

Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies

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12 December 2020

Oxidative alterations in Alzheimer's disease.

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12 December 2020

From Charcot to SOD1: mechanisms of selective motor neuron death in ALS.

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12 December 2020

Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis

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12 December 2020

A review of hemoglobin and the pathogenesis of cerebral vasospasm

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12 December 2020

Synthetic flavonoids cross the placenta in the rat and are found in fetal brain.

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12 December 2020

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

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12 December 2020

Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability.

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12 December 2020

Coffee drinking increases levels of urinary hydrogen peroxide detected in healthy human volunteers

1 reference

12 December 2020

Iron and oxygen radicals in brain

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12 December 2020

The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba

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12 December 2020

Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus.

1 reference

12 December 2020

Identification of hydrazine in commercial preparations of carnosine and its influence on carnosine's antioxidative properties.

1 reference

12 December 2020

Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

1 reference

12 December 2020

Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases a

1 reference

12 December 2020

Oxidative modification of glutamine synthetase by amyloid beta peptide.

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12 December 2020

Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.

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12 December 2020

Experimental models of Parkinson's disease: insights from many models

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12 December 2020

CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.

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12 December 2020

Vitamin C: poison, prophylactic or panacea?

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12 December 2020

The role of iron-sulfur clusters in in vivo hydroxyl radical production

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12 December 2020

Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

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12 December 2020

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

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12 December 2020

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

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12 December 2020

Glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration

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12 December 2020

Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia

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12 December 2020

The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia

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12 December 2020

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

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12 December 2020

Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase.

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12 December 2020

The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress

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12 December 2020

Promotion of oxidative damage to arachidonic acid and alpha 1-antiproteinase by anti-inflammatory drugs in the presence of the haem proteins myoglobin and cytochrome C.

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12 December 2020

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

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12 December 2020

Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases

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12 December 2020

Manganese ions, oxidation reactions and the superoxide radical

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12 December 2020

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

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12 December 2020

Ascorbate transport and intracellular concentration in cerebral astrocytes

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12 December 2020

Heme oxygenase: recent advances in understanding its regulation and role.

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12 December 2020

Dopamine turnover and glutathione oxidation: implications for Parkinson disease

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12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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12 December 2020

Regional distribution of catalase in the adult rat brain

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12 December 2020

Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group

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12 December 2020

Mechanisms for protection against copper toxicity

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12 December 2020

Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation

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12 December 2020

Caspases are reversibly inactivated by hydrogen peroxide

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12 December 2020

Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN).

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12 December 2020

Polymorphisms in the human DNA repair gene XPF.

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12 December 2020

Site-specific and random fragmentation of Cu,Zn-superoxide dismutase by glycation reaction. Implication of reactive oxygen species

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12 December 2020

The importance of inflammatory mechanisms in Alzheimer disease.

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12 December 2020

Effects of oxyradicals on oxymyoglobin. Deoxygenation, haem removal and iron release

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

DNA-damage & DNA-repair in ageing brain.

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12 December 2020

Prospects for pharmacological intervention in Alzheimer disease

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12 December 2020

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system.

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12 December 2020

Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis.

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12 December 2020

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro

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12 December 2020

Increased oxidative damage to DNA in ALS patients

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12 December 2020

Increased nuclear DNA oxidation in the brain in Alzheimer's disease.

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12 December 2020

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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12 December 2020

Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.

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12 December 2020

Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease

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12 December 2020

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

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12 December 2020

Aging and resistance to oxidative damage in Caenorhabditis elegans

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12 December 2020

Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia

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12 December 2020

Metabolism of xenobiotics in the central nervous system: implications and challenges.

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12 December 2020

Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin.

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12 December 2020

Phenyl N-tert-butyl nitrone forms nitric oxide as a result of its FE(III)-catalyzed hydrolysis or hydroxyl radical adduct formation

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12 December 2020

Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys

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12 December 2020

The toxicity in vitro of beta-amyloid protein

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12 December 2020

Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants.

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

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12 December 2020

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

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12 December 2020

Neurotoxicity risk assessment of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) as a synthetic impurity of drugs

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12 December 2020

Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains.

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12 December 2020

Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature

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12 December 2020

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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12 December 2020

Distribution of hydroxynonenal-modified proteins in the kainate-lesioned rat hippocampus: evidence that hydroxynonenal formation precedes neuronal cell death

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12 December 2020

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

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12 December 2020

Oxidative stress hypothesis in Alzheimer's disease

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12 December 2020

Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid

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12 December 2020

Enzymatic protection against peroxidative damage in isolated brain capillaries

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12 December 2020

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

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12 December 2020

Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus

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12 December 2020

Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage

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12 December 2020

Aberrant copper chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis

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12 December 2020

Chronic exposure to MPTP as a primate model of progressive parkinsonism: a pilot study with a free radical scavenger

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12 December 2020

Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.

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12 December 2020

The alpha-ketoglutarate dehydrogenase complex

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12 December 2020

Hypohaptoglobinemia associated with familial epilepsy

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12 December 2020

Cellular clones and transgenic mice overexpressing copper-zinc superoxide dismutase: models for the study of free radical metabolism and aging

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12 December 2020

Bleomycin-Detectable Iron in Brain Tissue

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12 December 2020

The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells.

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12 December 2020

The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.

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12 December 2020

Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy body disease

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12 December 2020

Plasma antioxidants and longevity: a study on healthy centenarians.

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12 December 2020

A quantitative study on the nigro-neostriatal dopamine neuron system in the rat.

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12 December 2020

Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization.

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12 December 2020

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

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12 December 2020

An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease.

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12 December 2020

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain

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12 December 2020

Expression and regulation of brain metallothionein.

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12 December 2020

Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders.

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12 December 2020

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.

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12 December 2020

Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease

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12 December 2020

Alpha-tocopherol levels in brain are not altered in Parkinson's disease

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12 December 2020

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia

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12 December 2020

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

12 December 2020

Hydrogen peroxide in the human body.

1 reference

12 December 2020

Endogenous nitric oxide synthesis: biological functions and pathophysiology

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12 December 2020

Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats.

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12 December 2020

Glutathione deficiency leads to mitochondrial damage in brain

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12 December 2020

Hypoxia, reactive oxygen, and cell injury

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12 December 2020

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides

1 reference

12 December 2020

CSF in Alzheimer's disease. Studies on blood-brain barrier function and intrathecal protein synthesis.

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12 December 2020

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12 December 2020

High doses of vitamin E in the treatment of disorders of the central nervous system in the aged

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12 December 2020

Increased CSF F2-isoprostane concentration in probable AD.

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Deprenyl suppresses the oxidant stress associated with increased dopamine turnover

1 reference

12 December 2020

Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-hydroxydopamine toxicity: involvement of the glutathione system

1 reference

12 December 2020

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

1 reference

12 December 2020

Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid

1 reference

12 December 2020

beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.

1 reference

12 December 2020

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Ovarian function in superoxide dismutase 1 and 2 knockout mice

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12 December 2020

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1 reference

12 December 2020

Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants.

1 reference

12 December 2020

Mutant CuZn superoxide dismutase in motor neuron disease

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12 December 2020

Oxidative stress, caloric restriction, and aging

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12 December 2020

The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans.

1 reference

12 December 2020

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.

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12 December 2020

Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease

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12 December 2020

Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease

1 reference

12 December 2020

Prevention of β-Amyloid Neurotoxicity by Blockade of the Ubiquitin-Proteasome Proteolytic Pathway

1 reference

12 December 2020

[Polyphenolic antioxidants in fruit juice. Urinary excretion and effects on biological markers for antioxidative status]

1 reference

12 December 2020

Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study

1 reference

12 December 2020

Cellular distribution of ferritin subunits in postnatal rat brain.

1 reference

12 December 2020

No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice

1 reference

12 December 2020

Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies

1 reference

12 December 2020

Methionine residues may protect proteins from critical oxidative damage.

1 reference

12 December 2020

1 reference

12 December 2020

Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps

1 reference

12 December 2020

Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.

1 reference

12 December 2020

Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine, 5-hydroxycytosine, and 2-hydroxyadenine: induction of SCE in human lymphocytes and mutagenicity in Salmonella typhimurium TA 100.

1 reference

12 December 2020

Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration

1 reference

12 December 2020

The preventative role of antioxidants (selegiline and vitamin E) in a rat model of tardive dyskinesia

1 reference

12 December 2020

Oxidative stress, human genetic variation, and disease

1 reference

12 December 2020

Abnormal localization of iron regulatory protein in Alzheimer's disease.

1 reference

12 December 2020

Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis

1 reference

12 December 2020

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

12 December 2020

Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics.

1 reference

12 December 2020

Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.

1 reference

12 December 2020

Variations in dietary iron alter brain iron metabolism in developing rats

1 reference

12 December 2020

BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy

1 reference

12 December 2020

Protein nitration in Parkinson's disease.

1 reference

12 December 2020

Apomorphine, a dopamine receptor agonist with remarkable antioxidant and cytoprotective properties.

1 reference

12 December 2020

Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron.

1 reference

12 December 2020

Iron release from metmyoglobin, methaemoglobin and cytochrome c by a system generating hydrogen peroxide

1 reference

12 December 2020

Redox regulation of the caspases during apoptosis

1 reference

12 December 2020

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

1 reference

12 December 2020

Binding of amyloid beta protein to the 20 S proteasome

1 reference

12 December 2020

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

12 December 2020

Superoxide anion radical (O2-.), superoxide dismutases, and related matters

1 reference

12 December 2020

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

12 December 2020

Thioredoxin reductase

1 reference

12 December 2020

Molecular manipulations of extracellular superoxide dismutase: functional importance for learning.

1 reference

12 December 2020

Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease

1 reference

12 December 2020

Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease.

1 reference

12 December 2020

Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency

1 reference

12 December 2020

Redox-active iron mediates amyloid-beta toxicity

1 reference

12 December 2020

Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases

1 reference

12 December 2020

cis-trans isomers of lycopene and beta-carotene in human serum and tissues

1 reference

12 December 2020

Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives

1 reference

12 December 2020

Biochemistry and pathology of radical-mediated protein oxidation

1 reference

12 December 2020

Aging, chromatin, and food restriction--connecting the dots

1 reference

12 December 2020

Microperoxisome distribution in the central nervous system of the rat

1 reference

12 December 2020

Role of MAO A and B in neurotransmitter metabolism and behavior

1 reference

12 December 2020

Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice.

1 reference

12 December 2020

Oxygen toxicity, oxygen radicals, transition metals and disease

1 reference

12 December 2020

Mitochondria, oxidative stress and aging.

1 reference

12 December 2020

Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus

1 reference

12 December 2020

Changes in glutathione in the hippocampus of rats injected with kainate: depletion in neurons and upregulation in glia

1 reference

12 December 2020

Multiple system atrophy: a sporadic synucleinopathy

1 reference

12 December 2020

Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction

1 reference

12 December 2020

Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin

1 reference

12 December 2020

Oxidative stress: free radical production in neural degeneration.

1 reference

12 December 2020

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1 reference

12 December 2020

Species differences in the generation of reactive oxygen species by microglia

1 reference

12 December 2020

Glutathione metabolism at the blood-cerebrospinal fluid barrier

1 reference

12 December 2020

Hypothesis: proteasomal dysfunction: a primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell death

1 reference

12 December 2020

Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease

1 reference

12 December 2020

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1 reference

12 December 2020

Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage.

1 reference

12 December 2020

Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype

1 reference

12 December 2020

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

1 reference

12 December 2020

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

12 December 2020

Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport

1 reference

12 December 2020

Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases

1 reference

12 December 2020

Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis.

1 reference

12 December 2020

Effect of high doses of dietary vitamin E on the concentrations of vitamin E in several brain regions, plasma, liver, and adipose tissue of rats.

1 reference

12 December 2020

The antioxidants of human extracellular fluids

1 reference

12 December 2020

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

12 December 2020

Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: less reactive oxidant formation but high spontaneous aggregation and precipitation

1 reference

12 December 2020

Neurochemical, neurophysiological, and neuropathological studies in vitamin E deficiency

1 reference

12 December 2020

Examining the evidence about treatment in ALS/MND.

1 reference

12 December 2020

No evidence for increased oxidative damage to lipids, proteins, or DNA in Huntington's disease

1 reference

12 December 2020

Cytotoxic and genotoxic potential of dopamine

1 reference

12 December 2020

Purification and properties of the 26S proteasome from the rat brain: evidence for its degradation of myelin basic protein in a ubiquitin-dependent manner

1 reference

12 December 2020

Nutrition and development: other micronutrients' effect on growth and cognition.

1 reference

12 December 2020

DNA repair pathways and cancer prevention

1 reference

12 December 2020

The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects

1 reference

12 December 2020

Regular exercise improves cognitive function and decreases oxidative damage in rat brain.

1 reference

12 December 2020

Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosine

1 reference

12 December 2020

Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system

1 reference

12 December 2020

Mitochondrial respiratory enzyme function and superoxide dismutase activity following brain glutathione depletion in the rat.

1 reference

12 December 2020

Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study

1 reference

12 December 2020

NADPH oxidase: an update

1 reference

12 December 2020

Alzheimer's disease, beta-amyloid protein and zinc

1 reference

12 December 2020

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

1 reference

12 December 2020

Differential expression of peroxiredoxin subtypes in human brain cell types

1 reference

12 December 2020

Hemoglobin and iron-evoked oxidative stress in the brain: protection by bile pigments, manganese and S-nitrosoglutathione.

1 reference

12 December 2020

Antioxidant properties of nitecapone (OR-462)

1 reference

12 December 2020

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

1 reference

12 December 2020

New quinolinic derivatives as centrally active antioxidants

1 reference

12 December 2020

Biological spin trapping. II. Toxicity of nitrone spin traps: dose-ranging in the rat

1 reference

12 December 2020

Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice.

1 reference

12 December 2020

Protein precipitation: a common etiology in neurodegenerative disorders?

1 reference

12 December 2020

Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy

1 reference

12 December 2020

Formation of hydroxyl radicals in biological systems. Does myoglobin stimulate hydroxyl radical formation from hydrogen peroxide?

1 reference

12 December 2020

1 reference

12 December 2020

Cell damage by excess CuZnSOD and Down's syndrome

1 reference

12 December 2020

F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease.

1 reference

12 December 2020

Mineralization in ferritin: an efficient means of iron storage

1 reference

12 December 2020

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1 reference

12 December 2020

A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease

1 reference

12 December 2020

Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.

1 reference

12 December 2020

Chroman amide 12P inhibition of lipid peroxidation and protection against learning and memory impairment

1 reference

12 December 2020

Distribution and antioxidant activity of a palm oil carotene fraction in rats

1 reference

12 December 2020

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

1 reference

12 December 2020

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.

1 reference

12 December 2020

Nigral dopaminergic cell loss in vitamin E deficient rats

1 reference

12 December 2020

Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system

1 reference

12 December 2020

Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study

1 reference

12 December 2020

Transferrin and transferrin receptor function in brain barrier systems

1 reference

12 December 2020

N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria.

1 reference

12 December 2020

Oxidative modification of creatine kinase BB in Alzheimer's disease brain.

1 reference

12 December 2020

Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains.

1 reference

12 December 2020

Inhibition of nitric oxide synthase as a potential therapeutic target

1 reference

12 December 2020

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

1 reference

12 December 2020

Fullerene-based antioxidants and neurodegenerative disorders

1 reference

12 December 2020

Cholinesterase inhibitors and Gingko extracts--are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least six months' duration.

1 reference

12 December 2020

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

1 reference

12 December 2020

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

12 December 2020

Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies.

1 reference

12 December 2020

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

1 reference

12 December 2020

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

12 December 2020

Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee

1 reference

12 December 2020

On the limited ability of superoxide to release iron from ferritin

1 reference

12 December 2020

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1 reference

12 December 2020

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

The gastrointestinal tract: a major site of antioxidant action?

1 reference

12 December 2020

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

12 December 2020

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

12 December 2020

Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy

1 reference

12 December 2020

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1 reference

12 December 2020

1 reference

12 December 2020

Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca(2+)-loaded brain neurons.

1 reference

12 December 2020

Dietary arginine alters time of symptom onset in Huntington's disease transgenic mice

1 reference

12 December 2020

Evidence of neuronal oxidative damage in Alzheimer's disease.

1 reference

12 December 2020

Hydroperoxide metabolism in mammalian organs

1 reference

12 December 2020

Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia

1 reference

12 December 2020

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

1 reference

12 December 2020

Role of free radicals and catalytic metal ions in human disease: an overview

1 reference

12 December 2020

Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.

1 reference

12 December 2020

Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum.

1 reference

12 December 2020

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group

1 reference

12 December 2020

Hemoglobin-based blood substitutes and the hazards of blood radicals

1 reference

12 December 2020

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

1 reference

12 December 2020

10.2165/00002512-200118090-00004

Identifiers

DOI

1 reference

PubMed ID

11599635

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11599635