(Q46792281)

25 December 2017

title

Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence (English)

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25 December 2017

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Amy M Barrios

1

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25 December 2017

Charles S Craik

series ordinal

2

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25 December 2017

language of work or name

English

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publication date

1 December 2002

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25 December 2017

Bioorganic & Medicinal Chemistry Letters

published in

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25 December 2017

volume

12

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25 December 2017

issue

24

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25 December 2017

page(s)

3619-3623

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25 December 2017

A taste test for proteases

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Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

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Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

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Definition and redesign of the extended substrate specificity of granzyme B.

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Substrate phage: selection of protease substrates by monovalent phage display

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Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

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Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles

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Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates

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Enzyme-amplified lanthanide luminescence for enzyme detection in bioanalytical assays

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Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings

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Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.

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Characterization of the S'-subsite specificity of bovine pancreatic alpha-chymotrypsin via acyl transfer to added nucleophiles.

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Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution

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The Cationminus signpi Interaction

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Identifiers

DOI

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25 December 2017

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25 December 2017