(Q46805949)

25 December 2017

title

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. (English)

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25 December 2017

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4

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Ilias Mylonis

object named as

Ilias Mylonis

series ordinal

1

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Efrosyni Paraskeva

object named as

Efrosyni Paraskeva

series ordinal

3

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author name string

Georgia Chachami

series ordinal

2

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25 December 2017

language of work or name

English

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publication date

7 August 2008

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25 December 2017

Journal of Biological Chemistry

published in

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25 December 2017

volume

283

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issue

41

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25 December 2017

page(s)

27620-27627

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25 December 2017

Hypoxia-inducible factor 1 (HIF-1) pathway

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803081200

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Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

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PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

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Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity

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Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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Accumulation and nuclear import of HIF1 alpha during high and low oxygen concentration in skeletal muscle cells in primary culture

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Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

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Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

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Bacterially produced human HIF-1alpha is competent for heterodimerization and specific DNA-binding.

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CRM1-mediated nuclear export: to the pore and beyond.

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Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role

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21 January 2018

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Leucine-rich nuclear-export signals: born to be weak

21 January 2018

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MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803081200

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25 December 2017

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25 December 2017