(Q46852217)

English

The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity.

scientific article published in December 2007

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scholarly article

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18077683

The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

Alzheimer's disease

0 references

1 reference

based on heuristic

inferred from title

toxic encephalopathy

1 reference

based on heuristic

inferred from title

author name string

Olga Simakova

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

Nelson J Arispe

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

language of work or name

0 references

publication date

1 December 2007

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18077683

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

27

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

13719-13729

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

50

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic signaling by beta-amyloid causes neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A receptor for phosphatidylserine-specific clearance of apoptotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and purification of aminophospholipid flippases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The levels of cerebrospinal fluid Abeta40 and Abeta42(43) are regulated age-dependently.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in myocardial ischaemia and infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of adenosine triphosphate from isolated adult heart cells in response to hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell volume and the regulation of apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divide and die: cell cycle events as triggers of nerve cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside-mediated accumulation of amyloid beta-protein on cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface exposure of phosphatidylserine in pathological cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early and late cytotoxic effects of external application of the Alzheimer's Abeta result from the initial formation and function of Abeta ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells. Evidence for a protein-mediated and ATP-dependent process(es)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane Asymmetry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular MTT reduction distinguishes the mechanism of action of beta-amyloid from that of tachykinin receptor peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiologic implications of membrane phospholipid asymmetry in blood cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3006-07.2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673638&resulttype=core&format=json

11 May 2020

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