(Q46852229)

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29 December 2019

title

Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms (English)

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29 December 2019

1 reference

8

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29 December 2019

author name string

Emmanuel Planel

1

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29 December 2019

Yoshitaka Tatebayashi

2

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29 December 2019

Tomohiro Miyasaka

3

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29 December 2019

Li Liu

4

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29 December 2019

Lili Wang

5

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29 December 2019

Mathieu Herman

6

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29 December 2019

W Haung Yu

7

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29 December 2019

Brian Wadzinski

9

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29 December 2019

Karen E Duff

10

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29 December 2019

Akihiko Takashima

11

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29 December 2019

language of work or name

English

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publication date

1 December 2007

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29 December 2019

published in

Journal of Neuroscience

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29 December 2019

volume

27

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29 December 2019

issue

50

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29 December 2019

page(s)

13635-13648

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Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration.

29 December 2019

cites work

1 reference

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Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders

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Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

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Effect of diabetes on calcium/calmodulin dependent protein kinase-II from rat brain

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New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin.

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Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells

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An anchoring factor targets protein phosphatase 2A to brain microtubules

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A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

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12 December 2020

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

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12 December 2020

A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events

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Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update

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The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

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12 December 2020

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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12 December 2020

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

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12 December 2020

Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease

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Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort.

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Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

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Alzheimer's disease: role of aging in pathogenesis

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12 December 2020

Does insulin dysfunction play a role in Alzheimer's disease?

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12 December 2020

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

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12 December 2020

The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

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Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

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12 December 2020

The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

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12 December 2020

Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology

1 reference

12 December 2020

Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice

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12 December 2020

Role of serine/threonine protein phosphatase in Alzheimer's disease

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12 December 2020

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

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12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

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12 December 2020

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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12 December 2020

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

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12 December 2020

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

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12 December 2020

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

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12 December 2020

Tissue-specific regulation of insulin receptor mRNA levels in rats with STZ-induced diabetes mellitus

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12 December 2020

Role for neuronal insulin resistance in neurodegenerative diseases

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12 December 2020

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

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12 December 2020

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Role of tau protein in both physiological and pathological conditions.

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12 December 2020

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

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12 December 2020

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

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12 December 2020

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

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12 December 2020

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

1 reference

12 December 2020

Pathogenesis of type 2 diabetes mellitus

1 reference

12 December 2020

Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau

1 reference

12 December 2020

Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

1 reference

12 December 2020

Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats.

1 reference

12 December 2020

Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

1 reference

12 December 2020

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

1 reference

12 December 2020

ELISA method for measurement of amyloid-beta levels.

1 reference

12 December 2020

The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse

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12 December 2020

Aggregation of vascular risk factors and risk of incident Alzheimer disease

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12 December 2020

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

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12 December 2020

Risk of dementia in diabetes mellitus: a systematic review

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12 December 2020

The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study

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12 December 2020

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.

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12 December 2020

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease

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12 December 2020

Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency

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12 December 2020

Pathways by which Abeta facilitates tau pathology

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12 December 2020

The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

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12 December 2020

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

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12 December 2020

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

1 reference

12 December 2020

Adiposity and Alzheimer's disease

1 reference

12 December 2020

Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.

1 reference

12 December 2020

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

12 December 2020

High resolution two-dimensional electrophoresis of proteins

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12 December 2020

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

1 reference

12 December 2020

The structure and regulation of protein phosphatases

1 reference

12 December 2020

Thermoregulatory responses of diabetic rats

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12 December 2020

Detrimental effect of chronic diabetes on growth and function of fetal islet isografts in mice

1 reference

12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

12 December 2020

Risk of hypothermia in elderly patients with diabetes

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12 December 2020

Diabetes mellitus and thermoregulation

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12 December 2020

Insulin binding to the blood-brain barrier in the streptozotocin diabetic rat.

1 reference

12 December 2020

Central nervous system insulin receptors in normal and diabetic rats

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12 December 2020

Brown Adipose Tissue Metabolism in Streptozotocin-Diabetic Rats*

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

Murine streptozotocin diabetes: influences of the major histocompatibility complex, genetic background and blood transfusion

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12 December 2020

Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus

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12 December 2020

Shivering thermogenesis and glucose uptake by muscles of normal or diabetic rats.

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12 December 2020

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

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12 December 2020

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

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12 December 2020

Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites.

1 reference

12 December 2020

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

12 December 2020

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

12 December 2020

Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location

1 reference

12 December 2020

STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

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12 December 2020

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

12 December 2020

Paired helical filament tau in Alzheimer's disease. The kinase connection

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12 December 2020

Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.

1 reference

12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

12 December 2020

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease.

1 reference

12 December 2020

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

12 December 2020

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

1 reference

12 December 2020

The significance of glucose turnover in the brain in the pathogenetic mechanisms of Alzheimer's disease

1 reference

12 December 2020

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

1 reference

12 December 2020

Effects of diabetes and food deprivation on shivering activity during progressive hypothermia in the rat.

1 reference

12 December 2020

Insulin receptor content in tissues of normal and diabetic rats measured by radioimmunoassay.

1 reference

12 December 2020

Aging, metabolism, and Alzheimer disease: review and hypotheses

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12 December 2020

Risk of dementia among persons with diabetes mellitus: a population-based cohort study

1 reference

12 December 2020

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

12 December 2020

The endocrinology of aging

1 reference

12 December 2020

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

1 reference

12 December 2020

Diabetes affects blood pressure and heart rate responses during acute hypothermia

1 reference

12 December 2020

Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits

1 reference

12 December 2020

Autoregulation of protein phosphatase type 2A expression

1 reference

12 December 2020

Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.

1 reference

12 December 2020

Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited.

1 reference

12 December 2020

Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase

1 reference

12 December 2020

10.1523/JNEUROSCI.3949-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077675%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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29 December 2019

PubMed publication ID

18077675

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