(Q46856522)

25 December 2017

title

Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity (English)

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25 December 2017

author name string

Tobias Klaassen

1

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25 December 2017

Alexander Jetter

2

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25 December 2017

Dorota Tomalik-Scharte

3

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25 December 2017

Dirk Kasel

4

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25 December 2017

Julia Kirchheiner

5

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25 December 2017

Ulrich Jaehde

6

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25 December 2017

Uwe Fuhr

7

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25 December 2017

publication date

11 December 2007

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25 December 2017

European Journal of Clinical Pharmacology

published in

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25 December 2017

volume

64

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25 December 2017

issue

4

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25 December 2017

page(s)

387-398

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25 December 2017

https://scigraph.springernature.com/pub.10.1007/s00228-007-0416-z

exact match

0 references

cites work

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00228-007-0416-Z

Limitation to the use of the urinary S-/R-mephenytoin ratio in pharmacogenetic studies

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00228-007-0416-Z

21 January 2018

Gerontokinetics--a reply

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https://api.crossref.org/works/10.1007%2FS00228-007-0416-Z

Sample size determination for bioequivalence assessment by means of confidence intervals

21 January 2018

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12 December 2020

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

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12 December 2020

Cytochrome P450 2C9 phenotyping using low-dose tolbutamide

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12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

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12 December 2020

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

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12 December 2020

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events

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12 December 2020

Phenotyping of CYP2C19 with enantiospecific HPLC-quantification of R- and S-mephenytoin and comparison with the intron4/exon5 G-->A-splice site mutation.

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12 December 2020

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

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12 December 2020

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

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12 December 2020

Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability

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12 December 2020

"Cocktail" approaches and strategies in drug development: valuable tool or flawed science?

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12 December 2020

Assessment of cytochrome P450 activity by a five-drug cocktail approach

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12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

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12 December 2020

Phenotypic-genotypic analysis of CYP2C19 in the Jewish Israeli population

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12 December 2020

CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population

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12 December 2020

Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin

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12 December 2020

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

1 reference

12 December 2020

Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure

1 reference

12 December 2020

Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".

1 reference

12 December 2020

Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man

1 reference

12 December 2020

Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.

1 reference

12 December 2020

Caution in the use of a 100 mg dose of racemic mephenytoin for phenotyping southeastern Oriental subjects

1 reference

12 December 2020

The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers

1 reference

12 December 2020

Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation

1 reference

12 December 2020

Determination of CYP2C19 phenotype in black Americans with omeprazole: correlation with genotype

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12 December 2020

An S-mephenytoin cysteine conjugate identified in urine of extensive but not of poor metabolizers of S-mephenytoin

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12 December 2020

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin

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12 December 2020

Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6.

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12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

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12 December 2020

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

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12 December 2020

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

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12 December 2020

Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism

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12 December 2020

Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach

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12 December 2020

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

1 reference

12 December 2020

Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method

1 reference

12 December 2020

The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians

1 reference

12 December 2020

Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers

1 reference

12 December 2020

Cytochrome P-450 activity is differentially altered in severely injured patients

1 reference

12 December 2020

Pharmacogenetics-based therapeutic recommendations — ready for clinical practice?

1 reference

12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

1 reference

12 December 2020

Examination of purported probes of human CYP2B6.

1 reference

12 December 2020

Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping

1 reference

12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

1 reference

12 December 2020

Bioequivalence revisited: influence of age and sex on CYP enzymes

1 reference

12 December 2020

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

12 December 2020

10.1007/S00228-007-0416-Z

Identifiers

DOI

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25 December 2017

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25 December 2017