(Q46863803)

25 December 2017

title

Acetylcholine nicotinic receptors: finding the putative binding site of allosteric modulators using the "blind docking" approach (English)

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25 December 2017

author name string

Bogdan Iorga

1

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25 December 2017

Denyse Herlem

2

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25 December 2017

Elvina Barré

3

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25 December 2017

Catherine Guillou

4

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25 December 2017

publication date

22 December 2005

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25 December 2017

Journal of Molecular Modeling

published in

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25 December 2017

volume

12

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25 December 2017

issue

3

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25 December 2017

page(s)

366-372

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25 December 2017

https://scigraph.springernature.com/pub.10.1007/s00894-005-0057-z

exact match

0 references

cites work

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Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation

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Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall.

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Mapping of a binding site for ATP within the extracellular region of the Torpedo nicotinic acetylcholine receptor beta-subunit

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Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution

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Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor

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Acetylcholinesterase inhibition in Alzheimer's Disease

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Cholinergic nicotinic receptors: Competitive ligands, allosteric modulators, and their potential applications

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The nicotinic receptor ligand binding domain

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Allosteric modulation of Torpedo nicotinic acetylcholine receptor ion channel activity by noncompetitive agonists.

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Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain

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Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction

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Multiple sequence alignment with the Clustal series of programs

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Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

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Identification of residues that confer alpha-conotoxin-PnIA sensitivity on the alpha 3 subunit of neuronal nicotinic acetylcholine receptors

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Mutations in the extracellular domain and in the membrane-spanning domains interfere with nicotinic acetylcholine receptor maturation

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Function and structure in glycine receptors and some of their relatives

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Structural changes during ion channel gating

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Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

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Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy

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Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands

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A structural model of agonist binding to the α3β4 neuronal nicotinic receptor

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Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site

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Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine

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A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions

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Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

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Nicotinic receptor modulation: advantages for successful Alzheimer's disease therapy

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Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease

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Efficient docking of peptides to proteins without prior knowledge of the binding site

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

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Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide

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Comparative protein modelling by satisfaction of spatial restraints

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The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections

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12 December 2020

10.1007/S00894-005-0057-Z

Identifiers

DOI

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25 December 2017

1 reference

25 December 2017