(Q46879353)

26 December 2017

title

Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity (English)

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26 December 2017

modulation of voltage-gated sodium channel activity in other organism

main subject

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envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism

GO:0044488

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envenomation resulting in modulation of voltage-gated sodium channel activity in other organism

GO:0044493

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positive regulation of voltage-gated sodium channel activity in other organism

GO:0044492

1 reference

envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism

GO:0044490

1 reference

negative regulation of voltage-gated sodium channel activity in other organism

GO:0044494

1 reference

3

Jan Tytgat

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26 December 2017

author name string

Annelies Van Der Haegen

series ordinal

1

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26 December 2017

Steve Peigneur

series ordinal

2

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26 December 2017

language of work or name

English

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publication date

24 August 2011

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26 December 2017

published in

FEBS Journal

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26 December 2017

volume

278

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26 December 2017

issue

18

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26 December 2017

page(s)

3408-3418

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26 December 2017

cites work

Conotoxins down under

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Conus peptides--a rich pharmaceutical treasure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Drugs from the sea: conopeptides as potential therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Conotoxin modulation of voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Disulfide-Depleted Selenoconopeptides: a Minimalist Strategy to Oxidative Folding of Cysteine-Rich Peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Novel Interactions Identified between μ-Conotoxin and the Na+ Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Oxidative folding of conotoxins sharing an identical disulfide bridging framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Critical molecular determinants of voltage-gated sodium channel sensitivity to mu-conotoxins GIIIA/B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Latent specificity of molecular recognition in sodium channels engineered to discriminate between two "indistinguishable" mu-conotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08264.X

10.1111/J.1742-4658.2011.08264.X

21 January 2018

Identifiers

DOI

1 reference

26 December 2017

1 reference

26 December 2017