(Q46890415)

26 December 2017

title

The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases (English)

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26 December 2017

author name string

Olga Khersonsky

series ordinal

1

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26 December 2017

Dan S Tawfik

series ordinal

2

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26 December 2017

language of work or name

English

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publication date

10 January 2006

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26 December 2017

Journal of Biological Chemistry

published in

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26 December 2017

volume

281

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26 December 2017

page(s)

7649-7656

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26 December 2017

issue

11

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26 December 2017

Pharmacogenetics of paraoxonases: a brief review

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

On the physiological role(s) of the paraoxonases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Lactonase and lactonizing activities of human serum paraoxonase (PON1) and rabbit serum PON3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

The active site of human paraoxonase (PON1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Approaches to DNA mutagenesis: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Enzyme catalysis: removing chemically 'essential' residues by site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Additivity of mutational effects in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Understanding nature's catalytic toolkit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Insights into the reaction mechanism of the diisopropyl fluorophosphatase from Loligo vulgaris by means of kinetic studies, chemical modification and site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512594200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512594200

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26 December 2017

PubMed ID

16407305

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26 December 2017