(Q46892912)

26 December 2017

title

Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors (English)

1 reference

26 December 2017

main subject

knowledge-based system

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4

Shyamal D Peddada

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26 December 2017

Marcus A Jackson

1

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26 December 2017

Isabel Lea

series ordinal

2

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26 December 2017

Asif Rashid

series ordinal

3

1 reference

26 December 2017

June K Dunnick

series ordinal

5

1 reference

26 December 2017

publication date

12 January 2006

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26 December 2017

published in

Toxicological Sciences

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26 December 2017

volume

90

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26 December 2017

issue

2

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26 December 2017

page(s)

400-418

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26 December 2017

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors

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21 January 2018

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Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice

21 January 2018

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Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

21 January 2018

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Mutations in the Ha-ras proto-oncogene in spontaneous and chemically induced liver tumours of the CF1 mouse.

21 January 2018

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Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice

21 January 2018

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INDUCTION OF SPECIFIC MUTATIONS WITH 5-BROMOURACIL.

21 January 2018

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Databases and tools for browsing genomes

21 January 2018

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Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study.

21 January 2018

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Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain. A study of 129 archival tumour samples

21 January 2018

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Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

21 January 2018

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Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis

21 January 2018

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Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas

21 January 2018

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Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191.

21 January 2018

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Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain

21 January 2018

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Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database.

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer.

21 January 2018

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Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.

21 January 2018

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Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Use of a multistrain assay could improve the NTP carcinogenesis bioassay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Serial analysis of gene expression and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Identification of two N2-deoxyguanosinyl DNA adducts upon nitroreduction of the environmental mutagen 1-nitropyrene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

ras mutations in 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumors in the CDF1 mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Does aflatoxin B1 play a role in the etiology of hepatocellular carcinoma in the United States?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

21 January 2018

Cancer statistics, 2005

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Hepatitis B and C virus infection and p53 mutations in human hepatocellular carcinoma in Harbin, Heilongjian Province, China

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Overview of cancer epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Expression of hepatocyte-enriched nuclear transcription factors in mouse liver tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Microsatellite instability and p53 mutations in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Roles of the Pas1 and Par2 genes in determination of the unique, intermediate susceptibility of BALB/cByJ mice to urethane-induction of lung carcinogenesis: differential effects on tumor multiplicity, size and Kras2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Role of Point Mutation of the K‐ras Gene in Tumorigenesis of B6C3F1 Mouse Lung Lesions Induced by Urethane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

p53 abnormalities in hepatocellular carcinoma from United States patients: analysis of all 11 exons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Topographic analysis of K- ras mutations in histologically normal lung tissues and tumours of lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Do we need genomic research for the prevention of common diseases with environmental causes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Hepatocarcinogenesis in BXH recombinant inbred strains of mice: analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinomas in Korean people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Aberrations of p53 gene in human hepatocellular carcinoma from China.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Benzo[b]fluoranthene: tumorigenicity in strain A/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

K-ras mutations in lung tumors from A/J and A/J×TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Detection of p53 gene mutations in human ovarian and endometrial cancers by polymerase chain reaction-single strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Cyclopenta[cd]pyrene-induced tumorigenicity, Ki-ras codon 12 mutations and DNA adducts in strain A/J mouse lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Specific Ki-ras codon 61 mutations may determine the development of urethan-induced mouse lung adenomas or adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Comparison of Ki-ras gene mutation among simultaneously occurring multiple urethan-induced lung tumors in individual mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Multiple molecular alterations in mouse lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylintrosamine or phenobarbitone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Dichloroacetic acid reduces Ha-ras codon 61 mutations in liver tumors from female B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Tumor-suppressor p53 gene in hepatitis C and B virus-associated human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

A sensitive restriction fragment length polymorphism method to detect CAA-->AAA mutations at codon 61 of Ha-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Proto-oncogene activation in liver tumors of hepatocarcinogenesis-resistant strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

p53 mutation in nonmelanoma skin cancers occurring in psoralen ultraviolet a-treated patients: evidence for heterogeneity and field cancerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Genetic heterogeneity of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Mutations of the Ki-ras protooncogene in 3-methylcholanthrene and urethan-induced and butylated hydroxytoluene-promoted lung tumors of strain A/J and SWR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

K-ras mutations in benzotrichloride-induced lung tumors of A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFJ101

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFJ101

1 reference

26 December 2017

1 reference

26 December 2017