(Q46914766)

English

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

scientific article published on 5 November 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

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1 reference

based on heuristic

inferred from title

chronic lymphocytic leukemia

1 reference

based on heuristic

inferred from title

author name string

K Lin

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

N Rockliffe

2

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

G G Johnson

3

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

P D Sherrington

4

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

A R Pettitt

5

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

language of work or name

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publication date

5 November 2007

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

27

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

17

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

2445-2455

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210893

0 references

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

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Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia.

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ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

1 reference

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Chronic lymphocytic leukemia

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Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

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Gain of function mutations in p53.

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Genomic aberrations and survival in chronic lymphocytic leukemia

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

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Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

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Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein

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Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

1 reference

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Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

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The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes

1 reference

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Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia

1 reference

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Transcriptional activities of mutant p53: when mutations are more than a loss

1 reference

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Cancer. p53, guardian of the genome

1 reference

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Mutant p53 protein expression interferes with p53-independent apoptotic pathways

1 reference

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21 January 2018

Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia.

1 reference

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High metastatic potential in mice inheriting a targeted p53 missense mutation

1 reference

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

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p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

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Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

1 reference

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Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

1 reference

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21 January 2018

Mutations in the p53 gene occur in diverse human tumour types

1 reference

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21 January 2018

ZAP-70 expression and prognosis in chronic lymphocytic leukaemia

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Decision making by p53: life, death and cancer

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Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms.

1 reference

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The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia.

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

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Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia

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Modulation of Akt kinase activity by binding to Hsp90

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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

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Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

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Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

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p53 Aberrations do not predict individual response to fludarabine in patients with B-cell chronic lymphocytic leukaemia in advanced stages Rai III/IV.

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Surfing the p53 network

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Hsp90 chaperones wild-type p53 tumor suppressor protein

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Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

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The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

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Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

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Increased expression of mutant forms of p53 oncogene in primary lung cancer

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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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The WHO classification of mature T-cell leukemias

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A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

1 reference

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Caspases influence the mode but not the extent of cell death induced by purine analogues in chronic lymphocytic leukaemia

1 reference

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1 reference

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Genomic Organization of the ATM gene

1 reference

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Identifiers

10.1038/SJ.ONC.1210893

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17982489

ResearchGate publication ID

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