(Q46927043)

English

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

scientific article published on 27 October 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Alzheimer's disease

0 references

prion protein family

0 references

neurodegeneration

1 reference

based on heuristic

inferred from title

Catarina R. Oliveira

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Paula M. Agostinho

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Joao P Lopes

1

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/17965932

publication date

27 October 2007

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Cellular and Molecular Neurobiology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

27

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

943-957

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17965932%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Cdk5, a therapeutic target for Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1007%2FS10571-007-9224-3

21 January 2018

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Sträussler-Scheinker syndrome P102L mutation complicated with dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cycling at the interface between neurodevelopment and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decade of CDK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BSE infection in bovine PrP transgenic mice leads to hyperphosphorylation of tau-protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Games played by rogue proteins in prion disorders and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid associated proteins in Alzheimer's and prion disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineating common molecular mechanisms in Alzheimer's and prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5 in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between amyloid and tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein aggregation and neurotoxicity in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17965932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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