(Q46931420)

26 December 2017

title

Haloperidol induces apoptosis via the sigma2 receptor system and Bcl-XS. (English)

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26 December 2017

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Wei Z

1

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26 December 2017

Mousseau DD

2

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26 December 2017

Dai Y

3

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26 December 2017

Cao X

4

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26 December 2017

Li XM

5

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26 December 2017

publication date

7 February 2006

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26 December 2017

The Pharmacogenomics Journal

published in

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26 December 2017

volume

6

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26 December 2017

issue

4

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26 December 2017

page(s)

279-288

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26 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500373

exact match

0 references

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Bcl-xS and Bax induce different apoptotic pathways in PC12 cells

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Bcl-x(S) induces an NGF-inhibitable cytochrome c release

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Atypical antipsychotics attenuate neurotoxicity of beta-amyloid(25-35) by modulating Bax and Bcl-X(l/s) expression and localization

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Breaking the mitochondrial barrier

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A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

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Review of the pharmacological and clinical profile of rimcazole.

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A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease

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A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.

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Purification, molecular cloning, and expression of the mammalian sigma1-binding site

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The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+]i in colon and mammary adenocarcinoma cells

21 January 2018

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol

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Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture

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Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

21 January 2018

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An increase of sigma receptors in the aged monkey brain.

21 January 2018

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Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test

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Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.

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21 January 2018

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Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

21 January 2018

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The effects of dose and duration of chronic pimozide administration on dopamine receptor supersensitivity

21 January 2018

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7 January 2021

Haloperidol-induced neurotoxicity--possible implications for tardive dyskinesia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

A proposal for the classification of sigma binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

Reduced haloperidol in the post-mortem brains of haloperidol-treated patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

Cytochrome c release from mitochondria: all or nothing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500373

7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500373

1 reference

26 December 2017

PubMed ID

16462815

1 reference

26 December 2017