(Q46944495)

26 December 2017

title

Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site (English)

1 reference

26 December 2017

main subject

Hyrtios erectus

object named as

Hyrtios erectus

1 reference

7

Xu Shen

1 reference

26 December 2017

author name string

Li Du

1

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26 December 2017

Liangliang Shen

2

1 reference

26 December 2017

Zhiguo Yu

3

1 reference

26 December 2017

Jing Chen

4

1 reference

26 December 2017

Yuewei Guo

5

1 reference

26 December 2017

Yun Tang

6

1 reference

26 December 2017

Hualiang Jiang

8

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26 December 2017

publication date

1 January 2008

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26 December 2017

published in

ChemMedChem

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26 December 2017

volume

3

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26 December 2017

issue

1

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26 December 2017

page(s)

173-180

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26 December 2017

Patented HIV-1 integrase inhibitors (1998-2005).

cites work

1 reference

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Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling.

21 January 2018

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7 January 2021

Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease

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7 January 2021

Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes

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7 January 2021

HIV-1 integrase: a target for new AIDS chemotherapeutics

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7 January 2021

Combinations of reverse transcriptase, protease, and integrase inhibitors can be synergistic in vitro against drug-sensitive and RT inhibitor-resistant molecular clones of HIV-1.

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7 January 2021

Structure and function of HIV-1 integrase

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7 January 2021

Substrate recognition by retroviral integrases

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7 January 2021

Integrase inhibitors to treat HIV/AIDS.

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7 January 2021

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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7 January 2021

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

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7 January 2021

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

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7 January 2021

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

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7 January 2021

HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial

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HIV-1 integrase inhibitors: 2003-2004 update

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7 January 2021

Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial

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A potent and orally active HIV-1 integrase inhibitor

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7 January 2021

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

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7 January 2021

Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays

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7 January 2021

Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures

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7 January 2021

Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in Vitro

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7 January 2021

The core domain of HIV-1 integrase recognizes key features of its DNA substrates

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7 January 2021

Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.

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7 January 2021

Mapping DNA-binding sites of HIV-1 integrase by protein footprinting

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7 January 2021

Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy

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7 January 2021

HIV-1 integrase crosslinked oligomers are active in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

1 reference

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7 January 2021

The Protein Data Bank

1 reference

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7 January 2021

Divalent cations stimulate preferential recognition of a viral DNA end by HIV-1 integrase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

An inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase

1 reference

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7 January 2021

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Three new scalarane sesterterpenoids from the Okinawan sponge Hyrtios erectus

1 reference

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7 January 2021

A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Validation of the general purpose Tripos 5.2 force field

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Development and validation of a genetic algorithm for flexible docking

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Improved protein-ligand docking using GOLD

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700223

7 January 2021

Identifiers

DOI

10.1002/CMDC.200700223

1 reference

26 December 2017

1 reference

26 December 2017