(Q46944998)

English

Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway

scientific article published on 18 October 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway (English)

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

1 reference

based on heuristic

inferred from title

author name string

Zhou J

1

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Pan M

2

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Xie Z

3

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Loh SL

4

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Bi C

5

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Tai YC

6

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Lilly M

7

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Lim YP

8

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Han JH

9

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Glaser KB

10

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Albert DH

11

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Davidsen SK

12

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

Chen CS

13

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

publication date

18 October 2007

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

22

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

138-146

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

1

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404960

0 references

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

The roles of FLT3 in hematopoiesis and leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

FLT3: ITDoes matter in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of FLT3 in haematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

AML1B transcriptional repressor function is impaired by the Flt3-internal tandem duplication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Validation of oligonucleotide microarray data using microfluidic low-density arrays: a new statistical method to normalize real-time RT-PCR data

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclins: roles in mitogenic signaling and oncogenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

What does Mos do in oocytes and somatic cells?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal expression of the MOS proto-oncogene in human thyroid medullary carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404960

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404960

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/17943175

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46944998&oldid=2139364001"