(Q46957363)

26 December 2017

title

Two-metal-ion mechanism for hammerhead-ribozyme catalysis (English)

1 reference

26 December 2017

author

Fabrice Leclerc

series ordinal

1

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26 December 2017

Martin Karplus

series ordinal

2

object named as

Martin Karplus

1 reference

26 December 2017

language of work or name

English

0 references

publication date

1 February 2006

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26 December 2017

Journal of Physical Chemistry B

published in

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26 December 2017

volume

110

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26 December 2017

issue

7

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26 December 2017

page(s)

3395-3409

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26 December 2017

Short-strong hydrogen bonds and a low barrier transition state for the proton transfer reaction in RNase A catalysis: a quantum chemical study

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Ribozyme-mediated cleavage of a substrate analogue containing an internucleotide-bridging 5'-phosphorothioate: evidence for the single-metal model

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Structure, folding and catalysis of the small nucleolytic ribozymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Mechanisms of Ribozyme-Mediated RNA Cleavage

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Steric interference modification of the hammerhead ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

The hammerhead cleavage reaction in monovalent cations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Functional analysis of the genes of yeast chromosome V by genetic footprinting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Biophysical and biochemical investigations of RNA catalysis in the hammerhead ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Kinetics of intermolecular cleavage by hammerhead ribozymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

A general two-metal-ion mechanism for catalytic RNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Catalytic role of metal ion in the selection of competing reaction paths: a first principles molecular dynamics study of the enzymatic reaction in ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Explanation by a putative triester-like mechanism for the thio effects and Mn2+ rescues in reactions catalyzed by a hammerhead ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Significant activity of a modified ribozyme with N7-deazaguanine at g10.1: the double-metal-ion mechanism of catalysis in reactions catalysed by hammerhead ribozymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Analysis on a cooperative pathway involving multiple cations in hammerhead reactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

A re-investigation of the thio effect at the hammerhead cleavage site

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and Mg2+ binding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Computer simulation and analysis of the reaction pathway of triosephosphate isomerase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Understanding the rates of certain enzyme-catalyzed reactions: proton abstraction from carbon acids, acyl-transfer reactions, and displacement reactions of phosphodiesters

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Double-Metal-Ion/Single-Metal-Ion Mechanisms of the Cleavage Reaction of Ribozymes: First-Principles Molecular Dynamics Simulations of a Fully Hydrated Model System.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP053835A

Identifiers

DOI

10.1021/JP053835A

1 reference

26 December 2017

1 reference

26 December 2017