(Q46979106)

27 December 2017

title

Model-based identification of drug targets that revert disrupted metabolism and its application to ageing (English)

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27 December 2017

4

Eytan Ruppin

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27 December 2017

author name string

Keren Yizhak

series ordinal

1

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27 December 2017

Orshay Gabay

series ordinal

2

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27 December 2017

Haim Cohen

series ordinal

3

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27 December 2017

language of work or name

English

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publication date

1 January 2013

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27 December 2017

published in

Nature Communications

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27 December 2017

volume

4

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27 December 2017

page(s)

2632

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27 December 2017

Systems biology in drug discovery

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A metabolic network approach for the identification and prioritization of antimicrobial drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Predicting selective drug targets in cancer through metabolic networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Integrating high-throughput and computational data elucidates bacterial networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Optimal regulatory strategies for metabolic pathways in Escherichia coli depending on protein costs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Multidimensional optimality of microbial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

An integrated approach to characterize genetic interaction networks in yeast metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Functional integration of a metabolic network model and expression data without arbitrary thresholding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Optimization-based framework for inferring and testing hypothesized metabolic objective functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Large-scale in silico modeling of metabolic interactions between cell types in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A community-driven global reconstruction of human metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Using the reconstructed genome-scale human metabolic network to study physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Metabolically re-modeling the drug pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Analysis of optimality in natural and perturbed metabolic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Gene expression profile of aging and its retardation by caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Aging and disease: connections to sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

The sirtuin SIRT6 regulates lifespan in male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Resveratrol and rapamycin: are they anti-aging drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Pathways change in expression during replicative aging in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A microarray-based genetic screen for yeast chronological aging factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Genes determining yeast replicative life span in a long-lived genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A genomic analysis of chronological longevity factors in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Sir2 blocks extreme life-span extension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Gene expression profile of aging in human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Transcriptional profiling of aging in human muscle reveals a common aging signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Endurance exercise as a countermeasure for aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Midlife gene expressions identify modulators of aging through dietary interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Biological aging alters circadian mechanisms in murine adipose tissue depots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Nutritional control of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A molecular mechanism of chronological aging in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Genome-scale models of microbial cells: evaluating the consequences of constraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Connecting extracellular metabolomic measurements to intracellular flux states in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Flux coupling analysis of genome-scale metabolic network reconstructions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

The chronological life span of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Manganese is the link between frataxin and iron-sulfur deficiency in the yeast model of Friedreich ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

Lessons on longevity from budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

The Edinburgh human metabolic network reconstruction and its functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

7 January 2021

Network-based prediction of human tissue-specific metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

7 January 2021

Influence of dietary sucrose on biological aging

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

7 January 2021

Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3632

7 January 2021

Identifiers

DOI

10.1038/NCOMMS3632

1 reference

27 December 2017

ADS bibcode

2013NatCo...4.2632Y

0 references

1 reference

27 December 2017