(Q46979323)

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Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1-42)-induced rat model of Alzheimer's disease.

scientific article published on 11 November 2013

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24151909%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1-42)-induced rat model of Alzheimer's disease (English)

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28 February 2020

Alzheimer's disease

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based on heuristic

inferred from title

Yigit Uyanıkgil

2

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28 February 2020

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E Turunc Bayrakdar

1

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28 February 2020

L Kanit

3

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28 February 2020

E Koylu

4

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28 February 2020

A Yalcin

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28 February 2020

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11 November 2013

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28 February 2020

Free Radical Research

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28 February 2020

48

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28 February 2020

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28 February 2020

146-158

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28 February 2020

Alzheimer disease: mechanistic understanding predicts novel therapies

1 reference

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Diagnosis and biomarkers of predementia in Alzheimer's disease.

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Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities

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The importance of neuritic plaques and tangles to the development and evolution of AD

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

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Pathways towards and away from Alzheimer's disease

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Apoptosis in neurodegenerative disorders

1 reference

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Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

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Protection against reactive oxygen species by selenoproteins

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Metabolism and functions of glutathione in brain.

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Oxidants and antioxidants revisited. New concepts of oxidative stress

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Neurovascular function in Alzheimer's disease patients and experimental models

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Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

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Behavioural and cellular effects of exogenous amyloid-β peptides in rodents

1 reference

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Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease

1 reference

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

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Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

1 reference

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21 January 2018

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease

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Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal

1 reference

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Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.

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21 January 2018

Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders

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21 January 2018

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

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21 January 2018

Poly(ADP-ribose). The most elaborate metabolite of NAD+.

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21 January 2018

Parthanatos, a messenger of death

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Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses

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21 January 2018

Poly(ADP-ribose) polymerase-1 in the nervous system

1 reference

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21 January 2018

Poly ADP-ribose polymerase-1 and health

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21 January 2018

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

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21 January 2018

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1 reference

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21 January 2018

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

1 reference

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21 January 2018

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1 reference

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21 January 2018

Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide

1 reference

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21 January 2018

Safety of high-dose nicotinamide: a review

1 reference

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21 January 2018

Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain

1 reference

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21 January 2018

The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways

1 reference

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21 January 2018

Nicotinamide is a potent inhibitor of proinflammatory cytokines

1 reference

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21 January 2018

Beneficial effects of melatonin on morphological changes in postnatal cerebellar tissue owing to epileptiform activity during pregnancy in rats: light and immunohistochemical study.

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21 January 2018

Influence of penicillin-induced epileptic activity during pregnancy on postnatal hippocampal nestin expression in rats: light and electron microscopic observations.

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21 January 2018

Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain

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Tissue sulfhydryl groups

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A simple method for determination of serum catalase activity and revision of reference range

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Relationship between red blood cell antioxidant enzymatic system status and lipoperoxidation during the acute phase of malaria

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Correlation between (3H)dopamine specific uptake and (3H)GBR 12783 specific binding during the maturation of rat striatum

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Inhibitory effects of ascorbic acid on dopamine uptake by rat striatal synaptosomes: relationship to lipid peroxidation and oxidation of protein sulfhydryl groups

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Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system

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Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide

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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

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Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

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Role of oxidative stress in the progression of Alzheimer's disease

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Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics

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Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures

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Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.

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Elevation of glutathione as a therapeutic strategy in Alzheimer disease

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Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

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Oxidative stress hypothesis in Alzheimer's disease

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Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease

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Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients

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Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.

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Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease

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Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

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Surfing the p53 network

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Role of p53 in neurodegenerative diseases

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Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

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Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.

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Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons

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Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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