(Q47035969)

3 January 2018

http://europepmc.org/abstract/MED/29056341

title

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. (English)

1 reference

3 January 2018

http://europepmc.org/abstract/MED/29056341

main subject

vitamin B12

0 references

vitamin B

0 references

negative regulation of cobalamin metabolic process

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0106122

regulation of cobalamin metabolic process

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0106064

positive regulation of cobalamin metabolic process

GOA release 2020-03-11

1 reference

Gene Ontology release 2020-05-02

1 reference

GOA release 2020-03-11

Citrate lyase beta like

1 reference

GOA release 2020-03-11

author

Hongying Shen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Zenon Grabarek

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

8

Vamsi K Mootha

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Gregory C Campanello

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Daniel Flicker

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Junchi Hu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Cheng Luo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ruma Banerjee

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

18 October 2017

1 reference

3 January 2018

http://europepmc.org/abstract/MED/29056341

published in

Cell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

171

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

771-782.e11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

4 June 2020

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

26 August 2018

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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity

26 August 2018

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26 August 2018

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The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases

26 August 2018

1 reference

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Better models by discarding data?

26 August 2018

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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

26 August 2018

1 reference

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Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

26 August 2018

1 reference

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26 August 2018

1 reference

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Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin

26 August 2018

1 reference

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26 August 2018

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Linking Crystallographic Model and Data Quality

26 August 2018

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A systematic survey of loss-of-function variants in human protein-coding genes

26 August 2018

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Itaconic acid is a mammalian metabolite induced during macrophage activation

26 August 2018

1 reference

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Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G

26 August 2018

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26 August 2018

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26 August 2018

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Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

26 August 2018

1 reference

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Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

26 August 2018

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26 August 2018

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26 August 2018

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Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus

26 August 2018

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A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria

26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

1 reference

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Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase

26 August 2018

1 reference

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New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

26 August 2018

1 reference

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When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase

26 August 2018

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The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes

26 August 2018

1 reference

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Inhibition of the human methylmalonyl-CoA mutase by various CoA-esters

26 August 2018

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Metabolism of ethylmalonate to mesaconate in the rat. Evidence for trans-dehydrogenation of methylsuccinate

26 August 2018

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Isolation of subunits of citrate lyase and characterization of their function in the enzyme complex

26 August 2018

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26 August 2018

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26 August 2018

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

10.1016/J.CELL.2017.09.051

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29056341%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference