(Q47071800)

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3 January 2020

title

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities (English)

1 reference

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3 January 2020

0 references

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GOA release 2020-03-11

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2

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3 January 2020

author name string

Cheng Wang

1

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3 January 2020

Xuezhi Ouyang

3

1 reference

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3 January 2020

Michelle W L Ho

4

1 reference

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3 January 2020

William Chia

5

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3 January 2020

Fengwei Yu

6

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3 January 2020

Kah-Leong Lim

7

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3 January 2020

language of work or name

English

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publication date

1 August 2007

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3 January 2020

published in

Journal of Neuroscience

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3 January 2020

volume

27

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3 January 2020

issue

32

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3 January 2020

page(s)

8563-8570

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Association between early-onset Parkinson's disease and mutations in the parkin gene

3 January 2020

cites work

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12 December 2020

Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene.

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12 December 2020

The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans

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12 December 2020

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

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12 December 2020

Complex relationship between Parkin mutations and Parkinson disease

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12 December 2020

Functional association of the parkin gene promoter with idiopathic Parkinson's disease

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

Parkin: a multipurpose neuroprotective agent?

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12 December 2020

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease

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12 December 2020

Neurodegeneration: how does parkin prevent Parkinson's disease?

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12 December 2020

Frequency of parkin mutations in late-onset Parkinson's disease.

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12 December 2020

Genetics of parkin-linked disease.

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12 December 2020

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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12 December 2020

Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.

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12 December 2020

Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation

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12 December 2020

Parkin-deficient mice are not a robust model of parkinsonism

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12 December 2020

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

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12 December 2020

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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12 December 2020

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

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12 December 2020

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

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12 December 2020

Dopamine covalently modifies and functionally inactivates parkin

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12 December 2020

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

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12 December 2020

Case-control study of the parkin gene in early-onset Parkinson disease.

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12 December 2020

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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12 December 2020

Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study

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12 December 2020

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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12 December 2020

Diagnosis and treatment of Parkinson disease: molecules to medicine

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12 December 2020

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

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12 December 2020

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

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12 December 2020

Deciphering the role of heterozygous mutations in genes associated with parkinsonism

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12 December 2020

10.1523/JNEUROSCI.0218-07.2007

Identifiers

DOI

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3 January 2020

1 reference

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3 January 2020

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