(Q47073658)

5 January 2018

title

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease (English)

1 reference

5 January 2018

Serine/threonine kinase 25a

main subject

1 reference

Programmed cell death 10b

GOA release 2020-03-11

1 reference

Programmed cell death 10a

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Bilge Yoruk

1

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5 January 2018

Benjamin S Gillers

2

1 reference

5 January 2018

Neil C Chi

3

1 reference

5 January 2018

Ian C Scott

4

1 reference

5 January 2018

language of work or name

English

0 references

publication date

11 December 2011

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5 January 2018

published in

Developmental Biology

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5 January 2018

volume

362

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5 January 2018

issue

2

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5 January 2018

page(s)

121-131

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5 January 2018

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

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Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

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Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype

7 January 2021

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Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

7 January 2021

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CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization

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Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype

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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

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Apoptotic functions of PDCD10/CCM3, the gene mutated in cerebral cavernous malformation 3.

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Foxn4 directly regulates tbx2b expression and atrioventricular canal formation

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Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells

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Mutations within the MGC4607 gene cause cerebral cavernous malformations

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Genotype-phenotype correlations in cerebral cavernous malformations patients

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KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

7 January 2021

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CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

7 January 2021

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Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.

7 January 2021

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Cerebral cavernous malformations: somatic mutations in vascular endothelial cells

7 January 2021

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KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

7 January 2021

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Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke

7 January 2021

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A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

7 January 2021

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Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.

7 January 2021

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Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21

7 January 2021

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Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development

7 January 2021

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Proteomic identification of the cerebral cavernous malformation signaling complex

7 January 2021

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ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

7 January 2021

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Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis

7 January 2021

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Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish

7 January 2021

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Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.

7 January 2021

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Genetics of cavernous angiomas

7 January 2021

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Endothelial cell migration during angiogenesis

7 January 2021

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CCM1 regulates vascular-lumen organization by inducing endothelial polarity

7 January 2021

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Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling

7 January 2021

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Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

7 January 2021

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Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

7 January 2021

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Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Cerebral cavernous malformation: new molecular and clinical insights

7 January 2021

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p53 activation by knockdown technologies

7 January 2021

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Towards a proteome-scale map of the human protein–protein interaction network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility

7 January 2021

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Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

High-resolution in situ hybridization to whole-mount zebrafish embryos

7 January 2021

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Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

7 January 2021

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Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Neurovascular development in the embryonic zebrafish hindbrain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.12.006

10.1016/J.YDBIO.2011.12.006

7 January 2021

Identifiers

DOI

1 reference

5 January 2018

1 reference

5 January 2018