(Q47094281)

8 January 2018

title

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis (English)

1 reference

8 January 2018

Onur Kanisicak

2

0 references

Jeffery D. Molkentin

Jeffery D Molkentin

12

0 references

Jason Karch

11

Jason Karch

1 reference

8 January 2018

Tobias G Schips

6

Tobias Schips

1 reference

8 January 2018

Robert N Correll

4

Robert N Correll

1 reference

8 January 2018

Ronald J Vagnozzi

7

Ronald J Vagnozzi

1 reference

8 January 2018

author name string

Hadi Khalil

1

1 reference

8 January 2018

Vikram Prasad

3

1 reference

8 January 2018

Xing Fu

5

1 reference

8 January 2018

Ruijie Liu

8

1 reference

8 January 2018

Thanh Huynh

9

1 reference

8 January 2018

Se-Jin Lee

10

1 reference

8 January 2018

language of work or name

English

0 references

publication date

11 September 2017

1 reference

8 January 2018

Journal of Clinical Investigation

published in

1 reference

8 January 2018

volume

127

1 reference

8 January 2018

issue

10

1 reference

8 January 2018

page(s)

3770-3783

1 reference

8 January 2018

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis

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23 May 2018

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TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

23 May 2018

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Genetic lineage tracing defines myofibroblast origin and function in the injured heart

23 May 2018

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Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

23 May 2018

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TGF-β: the master regulator of fibrosis

23 May 2018

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GATA4 regulates Fgf16 to promote heart repair after injury.

23 May 2018

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23 May 2018

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Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations

23 May 2018

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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

23 May 2018

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Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

23 May 2018

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Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.

23 May 2018

1 reference

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A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

23 May 2018

1 reference

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Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure

23 May 2018

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Pathological ventricular remodeling: therapies: part 2 of 2.

23 May 2018

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Caspase-3 protects stressed organs against cell death

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Synergistic roles of scleraxis and Smads in the regulation of collagen 1α2 gene expression

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney.

23 May 2018

1 reference

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Transforming growth factor (TGF)-β signaling in cardiac remodeling.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

New pharmacological treatments for improving renal outcomes in diabetes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Future treatments in systemic sclerosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Cardiac fibroblast: the renaissance cell

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Strategies for TGF-beta modulation: a review of recent patents

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Origin of cardiac fibroblasts and the role of periostin

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

The myofibroblast: paradigm for a mechanically active cell

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

The extracellular matrix: at the center of it all.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Hepatic fibrogenesis: from within and outwith

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Cellular and molecular mechanisms of fibrosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Identification of the gene transcription and apoptosis mediated by TGF-beta-Smad2/3-Smad4 signaling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Myofibroblast transdifferentiation in obliterative bronchiolitis: tgf-beta signaling through smad3-dependent and -independent pathways

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Morphometric analysis of coronary capillaries during physiologic myocardial growth and induced cardiac hypertrophy: a review

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Pleiotrophin induces formation of functional neovasculature in vivo.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617658

Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28891814

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28891814

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI94753

1 reference

8 January 2018

PMC publication ID

5617658

1 reference

8 January 2018

PubMed publication ID

28891814

1 reference

8 January 2018