(Q47137224)

9 January 2018

title

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model (English)

1 reference

9 January 2018

Rosalie C Sears

9

0 references

author name string

Mahnaz Janghorban

1

1 reference

9 January 2018

Ellen M Langer

2

1 reference

9 January 2018

Xiaoyan Wang

3

1 reference

9 January 2018

Derek Zachman

4

1 reference

9 January 2018

Colin J Daniel

5

1 reference

9 January 2018

Jody Hooper

6

1 reference

9 January 2018

William H Fleming

7

1 reference

9 January 2018

Anupriya Agarwal

8

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9 January 2018

language of work or name

English

0 references

publication date

30 November 2017

1 reference

9 January 2018

published in

PLOS One

1 reference

9 January 2018

volume

12

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9 January 2018

issue

11

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9 January 2018

page(s)

e0188910

1 reference

9 January 2018

Creative Commons Attribution 4.0 International

copyright license

start time

30 November 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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The protein phosphatase 2A regulatory subunit B56γ mediates suppression of T cell receptor (TCR)-induced nuclear factor-κB (NF-κB) activity

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23 May 2018

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BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

23 May 2018

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Identification of PP2A complexes and pathways involved in cell transformation

23 May 2018

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Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

23 May 2018

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Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal

23 May 2018

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The effect of c-myc on stem cell fate influences skin tumor phenotype

23 May 2018

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23 May 2018

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Reflecting on 25 years with MYC.

23 May 2018

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23 May 2018

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23 May 2018

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Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

23 May 2018

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Multiple pathways regulated by the tumor suppressor PP2A in transformation

23 May 2018

1 reference

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A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins

23 May 2018

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SV40 small T antigen and PP2A phosphatase in cell transformation

23 May 2018

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Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development

23 May 2018

1 reference

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

23 May 2018

1 reference

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Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.

23 May 2018

1 reference

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B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

23 May 2018

1 reference

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

23 May 2018

1 reference

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

The p53 pathway: positive and negative feedback loops

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Deregulated expression of c-Myc depletes epidermal stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Phosphorylation of Bcl2 and regulation of apoptosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Protein phosphatase 2A: the Trojan Horse of cellular signaling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Epithelial stem cells in the skin: definition, markers, localization and functions

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

Selection and extended growth of murine epidermal stem cells in culture

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708644

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29190822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The protein phosphatase 2A B56γ regulatory subunit is required for heart development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29190822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0188910

1 reference

9 January 2018

PMCID

5708644

1 reference

9 January 2018

PubMed ID

29190822

1 reference

9 January 2018