(Q47151966)

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Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC)

scientific article published in July 2012

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Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC) (English)

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author name string

Efsa Scientific Committee

1

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publication date

July 2012

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10

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Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and duration

1 reference

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Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks.

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Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

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Expression and function of cytochrome p450-dependent enzymes in human skin cells

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Alternatives to the carcinogenicity bioassay: in silico methods, and the in vitro and in vivo mutagenicity assays

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Exposure-triggered reproductive toxicity testing under the REACH legislation: a proposal to define significant/relevant exposure.

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REPDOSE: A database on repeated dose toxicity studies of commercial chemicals--A multifunctional tool

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TTC-based risk assessment of tetrachlorobutadienes and pentachlorobutadienes – The in vitro genotoxic contaminants in ground and drinking water

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Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products.

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A tiered approach to threshold of regulation.

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Toxicology. Transforming environmental health protection

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Estimation of toxic hazard—A decision tree approach

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A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung

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Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk.

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Toxicity assessment strategies, data requirements, and risk assessment approaches to derive health based guidance values for non-relevant metabolites of plant protection products

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The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans

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The concentration of no toxicological concern (CoNTC): a risk assessment screening tool for air toxics

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Quantification of the genetic risk of environmental mutagens

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Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food.

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Scientific evidence and common sense as a basis for food-packaging regulations

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The carcinogenesis bioassay in perspective: application in identifying human cancer hazards

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Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants

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A carcinogenic potency database of the standardized results of animal bioassays

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Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database

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Fenoterol metabolism in man: sulphation versus glucuronidation.

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Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology.

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Threshold of toxicological concern values for non-genotoxic effects in industrial chemicals: re-evaluation of the Cramer classification

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Developmental pharmacology--drug disposition, action, and therapy in infants and children

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Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing

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Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

1 reference

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The threshold of toxicological concern concept in risk assessment

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In silico techniques for the study and prediction of xenobiotic metabolism: a review

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Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern

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Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS Human Framework for the Analysis of a cancer mode of action for humans

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Application of the "threshold of toxicological concern" to derive tolerable concentrations of "non-relevant metabolites" formed from plant protection products in ground and drinking water

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Drug skin metabolites and allergic drug reactions

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Bisphenol A levels in blood depend on age and exposure.

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A regulatory approach to assess the potency of substances toxic to the reproduction

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Safety assessment procedures for indirect food additives: an overview. Report of a workshop

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A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives

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Ethylene oxide: evaluation of genotoxicity data and an exploratory assessment of genetic risk

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Prediction of ADMET Properties.

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Criteria employed by the expert panel of fema for the gras evaluation of flavouring substances

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An evaluation of the implementation of the Cramer classification scheme in the Toxtree software

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Teratogen update: vitamin A congeners

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Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents

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Structure-based thresholds of toxicological concern--guidance for application to substances present at low levels in the diet

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Screening health risk assessment of micropullutants for indirect potable reuse schemes: a three-tiered approach.

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A proposed approach for the assessment of chemicals in indirect potable reuse schemes.

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The Dermal Sensitisation Threshold- a TTC approach for allergic contact dermatitis.

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Refinement of the Dermal Sensitisation Threshold (DST) approach using a larger dataset and incorporating mechanistic chemistry domains

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Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model

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Skin sensitization in chemical risk assessment: report of a WHO/IPCS international workshop focusing on dose-response assessment

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The threshold of toxicological concern for prenatal developmental toxicity.

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DNA double-strand break repair in two radiation-sensitive mouse mammary carcinoma cell lines

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Identifiers

10.2903/J.EFSA.2012.2750

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