(Q35827686)

10 August 2017

1 reference

title

Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants (English)

1 reference

10 August 2017

1 reference

Gary Ginsberg

1

1 reference

10 August 2017

Dale Hattis

series ordinal

2

1 reference

10 August 2017

Babasaheb Sonawane

series ordinal

3

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10 August 2017

publication date

1 July 2004

1 reference

Toxicology and Applied Pharmacology

10 August 2017

published in

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10 August 2017

volume

198

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10 August 2017

issue

2

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10 August 2017

page(s)

164-183

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CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis

10 August 2017

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Absorption of drugs and other xenobiotics during development in experimental animals

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Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

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28 May 2022

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CYP 450 enzyme induction by chronic oral musk xylene in adult and developing rats.

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28 May 2022

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Phenobarbital disposition in adult and neonatal rabbits

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Clinical pharmacology of the perinatal period and early infancy

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Human physiologic factors in respiratory uptake of 1,3-butadiene

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

An in vitro study of diamorphine permeation through premature human neonatal skin

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Metabolism and cytotoxicity of aflatoxin b1 in cytochrome p-450-expressing human lung cells

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Anti-allergy and anti-asthma drugs. Disposition in infancy and childhood.

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The influence of age on the gastrointestinal absorption of mercuric chloride and methyl mercury chloride in the rat

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children

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28 May 2022

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Ontogeny of hepatic and renal systemic clearance pathways in infants: part II.

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Glucuronidation in humans. Pharmacogenetic and developmental aspects

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Cytochrome P-450 expression in sudden infant death syndrome

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

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28 May 2022

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Toxicokinetics in infants and children in relation to the ADI and TDI.

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Onset of xenobiotic metabolism in children: toxicological implications

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in fetal tissues of patas monkeys after transplacental exposure

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Comparison of the systemic availability of fluticasone propionate in healthy volunteers and patients with asthma

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Dose-dependent pharmacokinetics of caffeine in humans: relevance as a test of quantitative liver function

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Postnatal human lung growth

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Barrier properties of the newborn infant's skin

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Development of Alcohol Dehydrogenase Activity in the Human Liver

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The Development of Conjugation Mechanisms and Drug Toxicity in the Newborn

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Gastrointestinal absorption and retention of polonium in adult and newborn rats and guinea pigs

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Infant exposure to dioxin-like compounds in breast milk

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Acetaminophen elimination kinetics in neonates, children, and adults

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Carbamazepine metabolism in man. Induction and pharmacogenetic aspects

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Computer simulation of the lactational transfer of tetrachloroethylene in rats using a physiologically based model

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Caffeine acetylator phenotyping during maturation in infants

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Selective absorption of macromolecules into intestinal epithelium and blood by neonatal mice

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Theophylline metabolism during the first month of life and development

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature.

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Mechanism of transport and distribution of organic solvents in blood.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Glutathione status in retinopathy of prematurity

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Neonatal hepatic drug elimination

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Genotypes of N-acetyltransferase-2 and risk of bladder cancer: a case-control study.

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28 May 2022

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Extrapolation of physiological parameters for physiologically based simulation models

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28 May 2022

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The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence

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28 May 2022

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The role of different cytochrome P450 isoforms in in vitro chloroform metabolism

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28 May 2022

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Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.

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28 May 2022

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Skin permeability in the newborn

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28 May 2022

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Blood glutathione redox ratio as a parameter of oxidative stress in premature infants with IRDS

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The role of metabolism in the testing of developmental toxicants

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Three forms of trichloroethylene-metabolizing enzymes in rat liver induced by ethanol, phenobarbital, and 3-methylcholanthrene

1 reference

28 May 2022

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Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease

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28 May 2022

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Induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in mice foetuses by the PCB-congener 3,3',4,4'-tetrachlorobiphenyl

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28 May 2022

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Metabolism of theophylline by cDNA-expressed human cytochromes P-450.

1 reference

28 May 2022

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Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or beta-naphthoflavone

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation

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28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Development of the neonatal rat small intestinal barrier to nonspecific macromolecular absorption: effect of early weaning to artificial diets

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Effect of phorone-induced glutathione depletion on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Elimination and metabolic effects of ethanol in mother, fetus, and newborn infant

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Carbamazepine and its 10,11-epoxide in children and adults with epilepsy

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Disposition of parathion in neonatal and young pigs

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Effect of age on patterns of theophylline metabolism

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Mutagenic activation of aflatoxin B1 by P-450 HFLa in human fetal livers.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Differences in sensitivity of children and adults to chemical toxicity: the NAS panel report.

2 references

28 May 2022

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28 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1006/RTPH.2000.1393

Glutathione S-transferase in humans: development and tissue distribution

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Cytochrome P450 2E1: its clinical and toxicological role

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I).

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Blood lead slope factor models for adults: comparisons of observations and predictions

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

An analysis of the need for an additional uncertainty factor for infants and children

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Intestinal permeability changes during the first month: effect of natural versus artificial feeding.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Physiological-model-based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Factors affecting species differences in the kinetics of metabolites of trichloroethylene.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Developmental changes and polymorphism in human alcohol dehydrogenase.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Uncertainties in pharmacokinetic modeling for perchloroethylene: II. Comparison of model predictions with data for a variety of different parameters

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Maturation of AFMU excretion in infants

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Timing of the gut closure

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Extrapolation of in vitro enzyme induction data to humans in vivo

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Age and solubility of volatile anesthetics in blood.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Physiological "constants" for PBPK models for pregnancy

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Pharmacokinetic profile of caffeine in the premature newborn infant with apnea

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Percutaneous lignocaine absorption in newborn infants

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Transfer of drugs across the placenta

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Maturation of caffeine metabolic pathways in infancy

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Alterations in theophylline metabolism during the first year of life

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Enhancement of lipid peroxidation in rat liver on acute exposure to styrene and acrylamide a consequence of glutathione depletion.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Buthionine sulfoximine mediated enhancement of gamma-radiation induced mutation frequency in Drosophila melanogaster.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Glomerular filtration rate, effective renal blood flow, and maximal tubular excretory capacity in infancy

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Differences in pharmacokinetics between children and adults--II. Children's variability in drug elimination half-lives and in some parameters needed for physiologically-based pharmacokinetic modeling.

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Barriers in the immature brain

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

NAT2 gene polymorphism as a possible marker for susceptibility to bladder cancer in Japanese

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TAAP.2003.10.010

Identifiers

DOI

10.1016/J.TAAP.2003.10.010

1 reference

10 August 2017

1 reference