(Q47153078)

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Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and...

scientific article published in March 2013

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scholarly article

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Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the env (English)

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endocrine disruptor

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based on heuristic

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Efsa Scientific Committee

1

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publication date

March 2013

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11

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3

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3132

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Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

1 reference

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Two-step models to predict binding affinity of chemicals to the human estrogen receptor alpha by three-dimensional quantitative structure-activity relationships (3D-QSARs) using receptor-ligand docking simulation

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Toxicokinetic modeling and its applications in chemical risk assessment

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Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

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Science based guidance for the assessment of endocrine disrupting properties of chemicals.

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Altered mammary responsiveness to estradiol and progesterone in mice exposed neonatally to diethylstilbestrol

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IPCS framework for analyzing the relevance of a cancer mode of action for humans.

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IPCS framework for analyzing the relevance of a noncancer mode of action for humans

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Modelling and simulation in the pharmaceutical industry--some reflections

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Development and specification of physiologically based pharmacokinetic models for use in risk assessment

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Modelling the interaction of steroid receptors with endocrine disrupting chemicals

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QSAR model for human pregnane X receptor (PXR) binding: screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity

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21 January 2018

Hazard characterisation of chemicals in food and diet. dose response, mechanisms and extrapolation issues

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Scientific report of the Endocrine Active Substances Task Force

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Scientific Opinion on Risk Assessment for a Selected Group of Pesticides from the Triazole Group to Test Possible Methodologies to Assess Cumulative Effects from Exposure through Food from these Pesticides on Human Health

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Scientific Opinion on Evaluation of the Toxicological Relevance of Pesticide Metabolites for Dietary Risk Assessment

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Scientific Opinion on the science behind the development of a risk assessment of Plant Protection Products on bees (Apis mellifera,Bombusspp. and solitary bees)

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Statistical Significance and Biological Relevance

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Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate esters

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Environmental exposure assessment in European birth cohorts: results from the ENRIECO project

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In silico tools to aid risk assessment of endocrine disrupting chemicals

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Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor a

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The use of metabolising systems for in vitro testing of endocrine disruptors

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QSAR models for reproductive toxicity and endocrine disruption in regulatory use--a preliminary investigation

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Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent.

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Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop

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A critique of the use of hormesis in risk assessment

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Lifestyle behaviors associated with exposures to endocrine disruptors

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Impaired reproduction in three-spined sticklebacks exposed to ethinyl estradiol as juveniles.

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Risks to health and risks to science: the need for a responsible "bioevidential" scrutiny

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Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review

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Evaluation of the OECD (Q)SAR Application Toolbox for the profiling of estrogen receptor binding affinities.

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Hormesis and its place in nonmonotonic dose-response relationships: some scientific reality checks

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Effects of endocrine disruptors on obesity

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Performance comparison of various maximum likelihood nonlinear mixed-effects estimation methods for dose-response models

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Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?

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In silico-aided prediction of biological properties of chemicals: oestrogen receptor-mediated effects

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Decrease in anogenital distance among male infants with prenatal phthalate exposure

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Environmental endocrine disrupters

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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses

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VirtualToxLab - a platform for estimating the toxic potential of drugs, chemicals and natural products.

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Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism

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European birth cohorts for environmental health research

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Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society

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Identifiers

10.2903/J.EFSA.2013.3132

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