(Q37031081)

17 August 2017

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title

Development and specification of physiologically based pharmacokinetic models for use in risk assessment (English)

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17 August 2017

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2

Harvey J Clewell

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17 August 2017

Rebecca A Clewell

1

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17 August 2017

language of work or name

English

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publication date

6 November 2007

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Regulatory Toxicology and Pharmacology

17 August 2017

published in

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17 August 2017

volume

50

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17 August 2017

issue

1

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17 August 2017

page(s)

129-143

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Quantitative Relations in the Physiological Constitutions of Mammals

17 August 2017

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Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment

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Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

7 January 2021

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Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

7 January 2021

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Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene

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Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

7 January 2021

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Perchlorate and radioiodide kinetics across life stages in the human: using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage.

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Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans

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Development of a physiologically based pharmacokinetic model for chloroform

7 January 2021

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The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene

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Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment.

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Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output

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7 January 2021

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Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

7 January 2021

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Physiological Pharmacokinetic Analysis Using Population Modeling and Informative Prior Distributions

7 January 2021

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7 January 2021

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7 January 2021

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Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam

7 January 2021

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Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites

7 January 2021

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7 January 2021

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A partition coefficient determination method for nonvolatile chemicals in biological tissues.

7 January 2021

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Physiologically based pharmacokinetic modeling of inhaled 2-butoxyethanol in man

7 January 2021

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Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise

7 January 2021

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7 January 2021

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A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane.

7 January 2021

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Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment

7 January 2021

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Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species

7 January 2021

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Achieving credibility in risk assessment models

7 January 2021

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The importance of anatomical realism for validation of physiological models of disposition of inhaled toxicants

7 January 2021

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Determination of tissue to blood partition coefficients in physiologically-based pharmacokinetic studies.

7 January 2021

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Development and utilization of physiologically based pharmacokinetic models for toxicological applications

7 January 2021

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Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes

7 January 2021

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Incorporating human interindividual biotransformation variance in health risk assessment

7 January 2021

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Incorporation of pharmacokinetic and pharmacodynamic data into risk assessments

7 January 2021

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A physiologically based pharmacokinetic model for arsenic exposure. I. Development in hamsters and rabbits

7 January 2021

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A physiologically based pharmacokinetic model for arsenic exposure. II. Validation and application in humans

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A physiological pharmacokinetic model for dermal absorption of vapors in the rat*1

7 January 2021

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What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?

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A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise

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Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood

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Extended least squares nonlinear regression: a possible solution to the "choice of weights" problem in analysis of individual pharmacokinetic data

7 January 2021

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Variability of safe dose estimates when using complicated models of the carcinogenic process. A case study: methylene chloride.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2007.10.012

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2007.10.012

Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2007.10.012

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2007.10.012

The use and abuse of models

7 January 2021

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A pharmacodynamic model of triglyceride transport and deposition during feed deprivation or following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2007.10.012

A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons

7 January 2021

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Fate of [14C]vinyl chloride after single oral administration in rats

7 January 2021

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10.1016/J.YRTPH.2007.10.012

7 January 2021

Identifiers

DOI

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17 August 2017

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