(Q47202550)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway (English)

1 reference

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12 February 2020

1 reference

2

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12 February 2020

Tracey C. Dickson

series ordinal

3

1 reference

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12 February 2020

author name string

Ruth E J Musgrove

series ordinal

1

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12 February 2020

publication date

31 August 2012

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12 February 2020

published in

Neurotoxicity Research

1 reference

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12 February 2020

volume

23

1 reference

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12 February 2020

issue

4

1 reference

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12 February 2020

page(s)

358-369

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https://scigraph.springernature.com/pub.10.1007/s12640-012-9352-5

12 February 2020

exact match

0 references

cites work

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6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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alpha-Synuclein affects the MAPK pathway and accelerates cell death

21 January 2018

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Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

10.1007/S12640-012-9352-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference