(Q47215649)

19 February 2018

title

Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses (English)

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19 February 2018

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Hyun Jin Choi

1

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19 February 2018

Areum Park

2

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19 February 2018

Sujin Kang

3

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19 February 2018

Eunhye Lee

4

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19 February 2018

Taeyun A Lee

5

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19 February 2018

Eun A Ra

6

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19 February 2018

Jiseon Lee

7

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19 February 2018

Sungwook Lee

8

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19 February 2018

Boyoun Park

9

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19 February 2018

language of work or name

English

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publication date

9 January 2018

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19 February 2018

published in

Nature Communications

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19 February 2018

volume

9

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19 February 2018

issue

1

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19 February 2018

page(s)

125

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19 February 2018

Creative Commons Attribution 4.0 International

copyright license

start time

9 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/s41467-017-02624-8

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cites work

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23 May 2018

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MAVS protein is attenuated by rotavirus nonstructural protein 1

23 May 2018

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A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity

23 May 2018

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Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion

23 May 2018

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23 May 2018

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Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

23 May 2018

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Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

23 May 2018

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Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation

23 May 2018

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Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.

23 May 2018

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

23 May 2018

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

23 May 2018

1 reference

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MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

23 May 2018

1 reference

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Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production

23 May 2018

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Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity

23 May 2018

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Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function

23 May 2018

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IFI16 is an innate immune sensor for intracellular DNA

23 May 2018

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Mitochondrial protein import: from proteomics to functional mechanisms

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Pattern recognition receptors and inflammation

23 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains

23 May 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Diversity of degradation signals in the ubiquitin-proteasome system

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Setting the standards: quality control in the secretory pathway

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Targeting the NF-kappaB pathway through pharmacological inhibition of IKK2 prevents human cytomegalovirus replication and virus-induced inflammatory response in infected endothelial cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

Specificity of prion assembly in vivo. [PSI+] and [PIN+] form separate structures in yeast

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5760629

10.1038/S41467-017-02624-8

14 August 2018

Identifiers

DOI

1 reference

19 February 2018

0 references

1 reference

19 February 2018

PubMed ID

29317664

1 reference

19 February 2018