(Q47249680)

12 January 2018

title

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone (English)

1 reference

12 January 2018

1 reference

1

Richard E Taylor

1 reference

12 January 2018

author name string

Yue Chen

series ordinal

2

1 reference

12 January 2018

Gabriel M Galvin

series ordinal

3

1 reference

12 January 2018

Praveen K Pabba

series ordinal

4

1 reference

12 January 2018

language of work or name

1 reference

20 November 2003

1 reference

12 January 2018

Organic and Biomolecular Chemistry

published in

1 reference

12 January 2018

volume

2

1 reference

12 January 2018

issue

1

1 reference

12 January 2018

page(s)

127-132

1 reference

12 January 2018

Recent developments in the chemistry, biology and medicine of the epothilones

cites work

1 reference

Structure of the alpha beta tubulin dimer by electron crystallography

21 January 2018

1 reference

Microtubule structure at improved resolution

21 January 2018

1 reference

Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2

21 January 2018

1 reference

Natural product biosynthesis: a new interface between enzymology and medicine

21 January 2018

1 reference

Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum

21 January 2018

1 reference

Cloning and heterologous expression of the epothilone gene cluster.

21 January 2018

1 reference

Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F.

21 January 2018

1 reference

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

21 January 2018

1 reference

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

21 January 2018

1 reference

Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones

21 January 2018

1 reference

Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues

21 January 2018

1 reference

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

21 January 2018

1 reference

A common pharmacophore for cytotoxic natural products that stabilize microtubules

21 January 2018

1 reference

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

21 January 2018

1 reference

Reactions of alkenylchromium reagents prepared from alkenyl trifluoromethanesulfonates (triflates) with chromium(II) chloride under nickel catalysis

21 January 2018

1 reference

Concerning the diastereofacial selectivity of the aldol reactions of .alpha.-methyl chiral aldehydes and lithium and boron propionate enolates

21 January 2018

1 reference

Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivatives

21 January 2018

1 reference

Catalytic effect of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling reaction of iodo olefins with aldehydes

21 January 2018

1 reference

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

21 January 2018

1 reference

Chemical Biology of Epothilones

21 January 2018

1 reference

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

21 January 2018

1 reference

SAR and pH stability of cyano-substituted epothilones

21 January 2018

1 reference

A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone

21 January 2018

1 reference

Synthesis, structure proof, and biological activity of epothilone cyclopropanes

21 January 2018

1 reference

Synthesis and biological activity of novel epothilone aziridines

21 January 2018

1 reference

Total synthesis of epothilones B and D

21 January 2018

1 reference

Chiral synthesis via organoboranes. 7. Diastereoselective and enantioselective synthesis of erythro- and threo-.beta.-methylhomoallyl alcohols via enantiomeric (Z)- and (E)-crotylboranes

21 January 2018

1 reference

Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B312213C

1 reference

12 January 2018

1 reference

12 January 2018