(Q47259599)

English

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951.

scientific article published on 23 September 2010

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Europe PubMed Central

PubMed publication ID

12 January 2018

http://europepmc.org/abstract/MED/20861920

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951. (English)

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

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Pierre S Rohrlich

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Claude Preudhomme

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C Preudhomme

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H Cavé

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E Clappier

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S Collette

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N Grardel

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S Girard

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L Suarez

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G Brunie

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S Kaltenbach

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K Yakouben

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F Mazingue

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A Robert

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P Boutard

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D Plantaz

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P van Vlierberghe

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J Otten

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F Speleman

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N Dastugue

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S Suciu

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Y Benoit

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Y Bertrand

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EORTC-CLG

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publication date

23 September 2010

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2023-2031

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Acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

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Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

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Molecular pathogenesis of T-cell leukaemia and lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Notch signaling in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating Notch1 mutations in mouse models of T-ALL.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

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Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: a CLCG-EORTC report. Children Leukemia Cooperative Group

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

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Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

A competitive PCR-based method using TCRD, TCRG and IGH rearrangements for rapid detection of patients with high levels of minimal residual disease in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Treating childhood acute lymphoblastic leukemia without cranial irradiation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression profiling in T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

It's T-ALL about Notch

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

Correlating notch signaling with thymocyte maturation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.205

7 January 2021

based on heuristic

inferred from DOI database lookup

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

1 reference

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7 January 2021

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

1 reference

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7 January 2021

based on heuristic

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10.1038/LEU.2010.205

1 reference

Europe PubMed Central

PubMed publication ID

12 January 2018

http://europepmc.org/abstract/MED/20861920

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 January 2018

http://europepmc.org/abstract/MED/20861920

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