(Q47302451)

13 January 2018

title

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation (English)

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13 January 2018

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9

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13 January 2018

Alexander Schramm

11

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13 January 2018

Jean-Christophe Marine

13

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13 January 2018

David Nittner

David Nittner

1

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Frank Speleman

8

Frank Speleman

1 reference

13 January 2018

Irina Lambertz

2

Irina Lambertz

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13 January 2018

Søren Jensby Nielsen

6

Søren Jensby Nielsen

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13 January 2018

author name string

Frederic Clermont

3

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13 January 2018

Pieter Mestdagh

4

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13 January 2018

Corinna Köhler

5

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13 January 2018

Aart Jochemsen

7

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13 January 2018

Michael A Dyer

10

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13 January 2018

Johannes H Schulte

12

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13 January 2018

publication date

5 August 2012

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13 January 2018

published in

Nature Cell Biology

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13 January 2018

volume

14

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13 January 2018

issue

9

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13 January 2018

page(s)

958-965

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13 January 2018

https://scigraph.springernature.com/pub.10.1038/ncb2556

exact match

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cites work

The concept of synthetic lethality in the context of anticancer therapy

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Integrating genetic approaches into the discovery of anticancer drugs

21 January 2018

1 reference

Dicer1 functions as a haploinsufficient tumor suppressor

21 January 2018

1 reference

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

21 January 2018

1 reference

MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival

21 January 2018

1 reference

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

1 reference

Inactivation of the p53 pathway in retinoblastoma.

21 January 2018

1 reference

Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling

21 January 2018

1 reference

Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

21 January 2018

1 reference

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

21 January 2018

1 reference

Impaired microRNA processing enhances cellular transformation and tumorigenesis

21 January 2018

1 reference

RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

21 January 2018

1 reference

Down-regulation of dicer expression in ovarian cancer tissues.

21 January 2018

1 reference

DICER1 mutations in familial pleuropulmonary blastoma

21 January 2018

1 reference

Developmental defects in Rb-deficient retinae

21 January 2018

1 reference

Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter

21 January 2018

1 reference

Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina

21 January 2018

1 reference

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

21 January 2018

1 reference

Compensation by tumor suppressor genes during retinal development in mice and humans

21 January 2018

1 reference

Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a

21 January 2018

1 reference

Tumorigenicity of the miR-17-92 cluster distilled

21 January 2018

1 reference

MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc

21 January 2018

1 reference

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

21 January 2018

1 reference

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma

21 January 2018

1 reference

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters

21 January 2018

1 reference

Searching for synthetic lethality in cancer

21 January 2018

1 reference

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs

21 January 2018

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MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development

21 January 2018

1 reference

Essential role for Dicer during skeletal muscle development.

21 January 2018

1 reference

Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm

21 January 2018

1 reference

Dicer is required for the transition from early to late progenitor state in the developing mouse retina

21 January 2018

1 reference

High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA.

21 January 2018

1 reference

A novel and universal method for microRNA RT-qPCR data normalization

21 January 2018

1 reference

RDML: structured language and reporting guidelines for real-time quantitative PCR data

21 January 2018

1 reference

Role of Mdm4 in drug sensitivity of breast cancer cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22864477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The first knockout mouse model of retinoblastoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22864477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22864477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB2556

1 reference

13 January 2018

PubMed ID

22864477

1 reference

13 January 2018