(Q47367401)

14 January 2018

title

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR. (English)

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14 January 2018

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1

Elke Schaeffeler

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Ulrich M. Zanger

series ordinal

4

object named as

Ulrich M Zanger

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14 January 2018

author name string

Matthias Schwab

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2

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14 January 2018

Michel Eichelbaum

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3

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14 January 2018

publication date

1 December 2003

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14 January 2018

published in

Human Mutation

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14 January 2018

volume

22

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14 January 2018

issue

6

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14 January 2018

page(s)

476-485

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14 January 2018

Real-time quantitative polymerase chain reaction. A new method that detects both the peripheral myelin protein 22 duplication in Charcot-Marie-Tooth type 1A disease and the peripheral myelin protein 22 deletion in hereditary neuropathy with liabilit

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Novel approach to quantitative polymerase chain reaction using real-time detection: application to the detection of gene amplification in breast cancer

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Clinical significance of the sparteine/debrisoquine oxidation polymorphism

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The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry

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Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships

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10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

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The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

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Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction

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Pharmacogenetic phenotyping and genotyping. Present status and future potential.

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Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

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Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: evolutionary, toxicological, and clinical pharmacological aspects

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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

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PCR-based genotyping for duplicated and deleted CYP2D6 genes

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Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes

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CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages

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Characterization of the 16+9 kb and 30+9 kb CYP2D6 XbaI haplotypes

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Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

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Molecular mechanisms of genetic polymorphisms of drug metabolism

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Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6

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Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment

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Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction

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Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

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Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

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Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

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Identifiers

DOI

10.1002/HUMU.10280

1 reference

14 January 2018

1 reference

14 January 2018