(Q47410087)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

main subject

arterial hypertension

1 reference

based on heuristic

inferred from title

author

Evangelos D Michelakis

1

1 reference

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8 April 2020

Geoffrey Watson

5

1 reference

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8 April 2020

Luke S. Howard

6

1 reference

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8 April 2020

R B Thompson

9

1 reference

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8 April 2020

Declan P O'Regan

11

1 reference

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8 April 2020

Lan Zhao

12

1 reference

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8 April 2020

John Wharton

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

David G Kiely

14

1 reference

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8 April 2020

Aristeidis E Boukouris

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Chris W White

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Jayan Nagendran

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Darren Freed

19

1 reference

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8 April 2020

Martin Wilkins

22

1 reference

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8 April 2020

7

John Cupitt

1 reference

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8 April 2020

author name string

Vikram Gurtu

2

1 reference

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8 April 2020

Linda Webster

3

1 reference

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8 April 2020

Gareth Barnes

4

1 reference

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8 April 2020

Ian Paterson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Kelvin Chow

10

1 reference

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8 April 2020

Adam Kinnaird

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Stephen J Wort

20

1 reference

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8 April 2020

J Simon R Gibbs

21

1 reference

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8 April 2020

language of work or name

English

0 references

publication date

1 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

8 April 2020

published in

1 reference

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8 April 2020

volume

9

1 reference

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8 April 2020

issue

413

1 reference

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Pulmonary arterial hypertension: challenges in translational research and a vision for change

8 April 2020

cites work

1 reference

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Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

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Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

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Alterations of cellular bioenergetics in pulmonary artery endothelial cells

21 January 2018

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A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension

21 January 2018

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

21 January 2018

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Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.

21 January 2018

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Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans

21 January 2018

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Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.

21 January 2018

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UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria

21 January 2018

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Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.

21 January 2018

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Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)

21 January 2018

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

21 January 2018

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A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

21 January 2018

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Insulin resistance in pulmonary arterial hypertension

21 January 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

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Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Long-term safety of dichloroacetate in congenital lactic acidosis

21 January 2018

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Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

21 January 2018

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Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate

21 January 2018

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21 January 2018

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

21 January 2018

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A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

21 January 2018

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Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study

21 January 2018

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21 January 2018

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Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.

21 January 2018

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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

21 January 2018

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Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

21 January 2018

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The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

21 January 2018

1 reference

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A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation

21 January 2018

1 reference

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21 January 2018

1 reference

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Primary pulmonary hypertension: 3D dynamic perfusion MRI for quantitative analysis of regional pulmonary perfusion.

21 January 2018

1 reference

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10.1126/SCITRANSLMED.AAO4583

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29070699%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

1 reference