(Q28267156)

2

0 references

A Kinnaird

3

0 references

T H Stenson

4

0 references

A Haromy

5

0 references

J M R Parker

6

0 references

M S McMurtry

7

0 references

E D Michelakis

Why do cancers have high aerobic glycolysis?

8

0 references

language of work or name

English

0 references

publication date

28 March 2013

0 references

published in

Oncogene

0 references

volume

32

0 references

issue

13

0 references

page(s)

1638-50

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The role of mitochondria in pulmonary vascular remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Selection of cancer cells with repressed mitochondria triggers colon cancer progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Dichloroacetate induces apoptosis in endometrial cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Metabolic modulation of glioblastoma with dichloroacetate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Hypoxia, HIF1 and glucose metabolism in the solid tumour

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Hypoxia-inducible factor 1 (HIF-1) pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Hypoxia-inducible factors in physiology and medicine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Cytotoxicity, apoptosis and DNA damage induced by Alpinia galanga rhizome extract

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The mitochondrion in apoptosis: how Pandora's box opens

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Mitochondrial Membrane Potential in Living Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Redox regulation of p53 during hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

HIF-dependent antitumorigenic effect of antioxidants in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Hexokinase II: the integration of energy metabolism and control of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Regulation of angiogenesis by hypoxia: role of the HIF system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198

Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.198