(Q44452025)

English

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

scientific article published on 22 May 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 December 2017

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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Catherine Demazy

4

object named as

Catherine Demazy

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1

object named as

Denis Mottet

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

6

object named as

Martine Raes

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Europe PubMed Central

PubMed publication ID

3 December 2017

author name string

Valéry Dumont

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Yann Deccache

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Catherine Demazy

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Noelle Ninane

5

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Carine Michiels

7

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

language of work or name

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publication date

22 May 2003

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Europe PubMed Central

PubMed publication ID

3 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

3 December 2017

278

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Europe PubMed Central

PubMed publication ID

3 December 2017

33

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Europe PubMed Central

PubMed publication ID

3 December 2017

31277-31285

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Europe PubMed Central

PubMed publication ID

3 December 2017

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

ERK activation upon hypoxia: involvement in HIF-1 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300763200

21 January 2018

Identifiers

10.1074/JBC.M300763200

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

ResearchGate publication ID

0 references

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