(Q47549492)

English

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

scientific article published on 24 January 2018

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

phase I clinical trial

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

Martin R Gaudinski

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Carolyn Laurencot

15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Janardan P Pandey

20

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

22

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Edmund Capparelli

24

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

John R. Mascola

26

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Barney S. Graham

25

object named as

Barney S Graham

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Julie Ledgerwood

27

object named as

Julie E Ledgerwood

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Ingelise J Gordon

8

object named as

Ingelise Gordon

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

23

object named as

Richard A Koup

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Adrian B. McDermott

18

object named as

Adrian B McDermott

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

LaSonji A. Holman

7

object named as

LaSonji A Holman

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Cynthia S. Hendel

10

object named as

Cynthia S Hendel

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Richard M Schwartz

21

object named as

Richard M Schwartz

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Sandeep R Narpala

17

object named as

Sandeep Narpala

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Galina V Yamshchikov

5

object named as

Galina Yamshchikov

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Katherine V Houser

3

object named as

Katherine V Houser

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

13

object named as

Sandra Sitar

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2

object named as

Emily E Coates

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

14

object named as

Kevin Carlton

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Michelle Conan-Cibotti

11

object named as

Michelle Conan-Cibotti

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Margarita Gomez Lorenzo

12

object named as

Margarita Gomez Lorenzo

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Aryan M Namboodiri

19

object named as

Aryan M Namboodiri

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Sarah H. Plummer

9

object named as

Sarah Plummer

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Jamie G Saunders

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Robert T Bailer

16

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

VRC 606 Study Team

28

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

0 references

publication date

24 January 2018

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

e1002493

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

copyright license

Creative Commons CC0 License

24 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Identification and specificity of broadly neutralizing antibodies against HIV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Use of broadly neutralizing antibodies for HIV-1 prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

B-cell responses to HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Genetic markers of immunoglobulin G and immunity to cytomegalovirus in patients with breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Targeting FcRn for the modulation of antibody dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

HIV broadly neutralizing antibody targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Ending AIDS--is an HIV vaccine necessary?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

HIV-1 neutralizing antibodies: understanding nature's pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Neonatal Fc receptor and IgG-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Enhanced antibody half-life improves in vivo activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Engineered human IgG antibodies with longer serum half-lives in primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

22 May 2018

Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Statistical methods and tool for cut point analysis in immunogenicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

An engineered human IgG1 antibody with longer serum half-life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Quantitative methods for developing Fc mutants with extended half-lives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5783347

14 August 2018

Identifiers

10.1371/JOURNAL.PMED.1002493

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29364886%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q47549492&oldid=2143785755"