(Q47595845)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25312912%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme (English)

1 reference

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21 February 2020

3

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21 February 2020

Jose Manuel Sanchez Ruiz

4

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21 February 2020

author name string

Taisong Zou

1

1 reference

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21 February 2020

Valeria A Risso

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25312912%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

S Banu Ozkan

5

1 reference

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21 February 2020

publication date

13 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25312912%20AND%20SRC:MED&resulttype=core&format=json

Molecular Biology and Evolution

21 February 2020

published in

1 reference

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21 February 2020

volume

32

1 reference

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21 February 2020

issue

1

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21 February 2020

page(s)

132-143

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25312912%20AND%20SRC:MED&resulttype=core&format=json

Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil

21 February 2020

cites work

1 reference

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Protonation of the beta-lactam nitrogen is the trigger event in the catalytic action of class A beta-lactamases

21 January 2018

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Anisotropy of fluctuation dynamics of proteins with an elastic network model

21 January 2018

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Perturbation-response scanning reveals ligand entry-exit mechanisms of ferric binding protein

21 January 2018

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Manipulation of Conformational Change in Proteins by Single-Residue Perturbations

21 January 2018

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What makes an enzyme promiscuous?

21 January 2018

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Global dynamics of proteins: bridging between structure and function

21 January 2018

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The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases

21 January 2018

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The role of dynamic conformational ensembles in biomolecular recognition

21 January 2018

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The binding affinities of proteins interacting with the PDZ domain of PICK1.

21 January 2018

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The CTX-M beta-lactamase pandemic.

21 January 2018

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Structure and kinetics of the beta-lactamase mutants S70A and K73H from Staphylococcus aureus PC1

21 January 2018

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Enzymes with extra talents: moonlighting functions and catalytic promiscuity

21 January 2018

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The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

21 January 2018

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Antibiotic resistance is ancient

21 January 2018

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Indexing by latent semantic analysis

21 January 2018

1 reference

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NMR investigation of Tyr105 mutants in TEM-1 beta-lactamase: dynamics are correlated with function.

21 January 2018

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Modeling catalytic promiscuity in the alkaline phosphatase superfamily

21 January 2018

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POVME: an algorithm for measuring binding-pocket volumes

21 January 2018

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Titration_DB: storage and analysis of NMR-monitored protein pH titration curves

21 January 2018

1 reference

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Evolution of increased complexity in a molecular machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Specialized Dynamical Properties of Promiscuous Residues Revealed by Simulated Conformational Ensembles

21 January 2018

1 reference

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Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach

21 January 2018

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Structural dynamics flexibility informs function and evolution at a proteome scale

21 January 2018

1 reference

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Change in allosteric network affects binding affinities of PDZ domains: analysis through perturbation response scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Collective dynamics differentiates functional divergence in protein evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Analyzing protein structure and function using ancestral gene reconstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

On the origin and evolution of thermophily: reconstruction of functional precambrian enzymes from ancestors of Bacillus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Exploring the factors determining the dynamics of different protein folds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Conservation of Protein Structure over Four Billion Years

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Enzyme recruitment in evolution of new function

21 January 2018

1 reference

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Allostery and population shift in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Enhancing catalytic promiscuity for biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Enzyme promiscuity: evolutionary and mechanistic aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Enzyme promiscuity: a mechanistic and evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Spectral biclustering of microarray data: coclustering genes and conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Evolutionary history and metabolic insights of ancient mammalian uricases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Mechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Targeting biomolecular flexibility with metadynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Antibacterial resistance worldwide: causes, challenges and responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

The interface of protein structure, protein biophysics, and molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Promiscuity in alkaline phosphatase superfamily. Unraveling evolution through molecular simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Evolutionary conservation of protein backbone flexibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Comparing proteins by their internal dynamics: exploring structure-function relationships beyond static structural alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

The role of flexibility and conformational selection in the binding promiscuity of PDZ domains

21 January 2018

1 reference

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Protein promiscuity and its implications for biotechnology

21 January 2018

1 reference

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Catalytic promiscuity and the evolution of new enzymatic activities

21 January 2018

1 reference

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Exploring protein native states and large-scale conformational changes with a modified generalized born model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Comparative molecular dynamics--similar folds and similar motions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern

21 January 2018

1 reference

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Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins

21 January 2018

1 reference

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Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases

21 January 2018

1 reference

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Thermostable and promiscuous Precambrian proteins

21 January 2018

1 reference

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Coupling of replica exchange simulations to a non-Boltzmann structure reservoir

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Biophysics of protein evolution and evolutionary protein biophysics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Replica-exchange molecular dynamics method for protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

An Antibiotic-Resistance Enzyme from a Deep-Sea Bacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Conformational selection or induced fit? A critical appraisal of the kinetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Constrained geometric simulation of diffusive motion in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Predicting the clinical status of human breast cancer by using gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

Multidimensional epistasis and fitness landscapes in enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSU281

21 January 2018

Identifiers

DOI

10.1093/MOLBEV/MSU281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25312912%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference