(Q47621282)

4 February 2018

title

The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels (English)

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4 February 2018

author

Yehu Moran

5

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4 February 2018

author name string

Maya Gur Barzilai

1

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4 February 2018

Roy Kahn

2

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4 February 2018

Noa Regev

3

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4 February 2018

Dalia Gordon

4

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4 February 2018

Michael Gurevitz

6

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4 February 2018

language of work or name

English

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publication date

1 October 2014

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4 February 2018

published in

Biochemical Journal

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4 February 2018

volume

463

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4 February 2018

issue

2

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4 February 2018

page(s)

271-277

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4 February 2018

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

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Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains

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Sodium channel inactivation is altered by substitution of voltage sensor positive charges

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Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements

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Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation

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Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

21 January 2018

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Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

21 January 2018

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The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.

21 January 2018

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Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

21 January 2018

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The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

21 January 2018

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Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels

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Scorpion toxins specific for Na+-channels

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The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control

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Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin.

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Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel.

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Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features

21 January 2018

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Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on voltage-gated sodium channels.

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Peptide toxins in sea anemones: structural and functional aspects

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A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

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Three-dimensional structure in solution of neurotoxin III from the sea anemone Anemonia sulcata

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Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels

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Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels

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Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor

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21 January 2018

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Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity

21 January 2018

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Molecular interaction of delta-conotoxins with voltage-gated sodium channels.

21 January 2018

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Isolation and characterisation of three polypeptides with neurotoxic activity from Anemonia sulcata

21 January 2018

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Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus and Actinodendron plumosum

21 January 2018

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Improved insecticidal toxicity by fusing Cry1Ac of Bacillus thuringiensis with Av3 of Anemonia viridis

21 January 2018

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Effects of the sea anemone Anemonia sulcata toxin II on skeletal muscle and on neuromuscular transmission

21 January 2018

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Molecular basis of the high insecticidal potency of scorpion alpha-toxins

21 January 2018

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The Cambrian conundrum: early divergence and later ecological success in the early history of animals

21 January 2018

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Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer

21 January 2018

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Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20140576

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20140576

Structural parts involved in activation and inactivation of the sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140576

21 January 2018

Identifiers

DOI

10.1042/BJ20140576

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4 February 2018

PubMed ID

25055135

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4 February 2018