(Q47633699)

4 February 2018

title

From empiricism to rational design: a personal perspective of the evolution of vaccine development (English)

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4 February 2018

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Rino Rappuoli

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4 February 2018

Ennio De Gregorio

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4 February 2018

publication date

13 June 2014

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4 February 2018

Nature Reviews Immunology

published in

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4 February 2018

volume

14

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4 February 2018

issue

7

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4 February 2018

page(s)

505-514

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4 February 2018

Contagious diseases in the United States from 1888 to the present.

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Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.

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Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus

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Identification of a universal Group B streptococcus vaccine by multiple genome screen

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Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli

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Chlamydia pneumoniae genome sequence analysis and identification of HLA-A2-restricted CD8+ T cell epitopes recognized by infection-primed T cells.

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Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis

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Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis

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Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

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Rational design of a meningococcal antigen inducing broad protective immunity

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Creation of a bacterial cell controlled by a chemically synthesized genome

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Synthetic generation of influenza vaccine viruses for rapid response to pandemics

21 January 2018

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A cell culture-derived MF59-adjuvanted pandemic A/H7N9 vaccine is immunogenic in adults

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Nonviral delivery of self-amplifying RNA vaccines

21 January 2018

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Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice.

21 January 2018

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New adjuvants for human vaccines

21 January 2018

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Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

21 January 2018

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Adjuvant solution for pandemic influenza vaccine production

21 January 2018

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Development of an AS04-adjuvanted HPV vaccine with the adjuvant system approach

21 January 2018

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

21 January 2018

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Immunogenicity and safety of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in patients with chronic kidney disease.

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Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Global analyses of human immune variation reveal baseline predictors of postvaccination responses

21 January 2018

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Influenza: options to improve pandemic preparation

21 January 2018

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Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

21 January 2018

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Formaldehyde treatment and safety testing of experimental poliomyelitis vaccines

21 January 2018

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31 March 2020

New rotavirus vaccines

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Development and phase 1 clinical testing of a conjugate vaccine against meningococcus A and C

31 March 2020

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Meningococcal conjugate vaccines

31 March 2020

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31 March 2020

A sweet T cell response

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Mutants of pertussis toxin suitable for vaccine development

31 March 2020

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Rational design of vaccines

31 March 2020

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Candidate Neisseria meningitidis NspA vaccine

31 March 2020

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In Vaccine Design, Looks Do Matter

31 March 2020

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Oil-in-water emulsion adjuvant with influenza vaccine in young children

31 March 2020

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31 March 2020

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31 March 2020

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12 December 2020

The eradication of smallpox, a success story for modern medicine and public health: what lessons for the future?

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12 December 2020

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12 December 2020

Prevention of pneumococcal pneumonia by vaccination

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12 December 2020

China and the origins of immunology

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12 December 2020

Attenuation of RA 27/3 Rubella Virus in WI-38 Human Diploid Cells

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12 December 2020

Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide

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12 December 2020

Development and chimpanzee testing of a vaccine against human hepatitis B.

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12 December 2020

Haemophilus influenzae type B polysaccharide-protein conjugates: model for a new generation of capsular polysaccharide vaccines

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12 December 2020

Identifiers

DOI

10.1038/NRI3694

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4 February 2018

PMC publication ID

7096907

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4 February 2018