(Q47642087)

English

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway.

scientific article published on 9 December 2017

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scholarly article

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13 March 2020

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway (English)

1 reference

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13 March 2020

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based on heuristic

inferred from title

regulation of ferroptosis

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molecular biology

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6

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13 March 2020

author name string

Meng-Shian Chen

1

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13 March 2020

Sheng-Fan Wang

2

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13 March 2020

Chih-Yi Hsu

3

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13 March 2020

Pen-Hui Yin

4

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13 March 2020

Tien-Shun Yeh

5

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13 March 2020

Ling-Ming Tseng

7

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13 March 2020

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9 December 2017

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13 March 2020

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13 March 2020

8

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13 March 2020

70

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13 March 2020

114588-114602

1 reference

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13 March 2020

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

1 reference

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22 May 2018

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

1 reference

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22 May 2018

The integrated stress response.

1 reference

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22 May 2018

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas.

1 reference

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22 May 2018

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

1 reference

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22 May 2018

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

1 reference

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22 May 2018

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

1 reference

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22 May 2018

Glutaminolysis and Transferrin Regulate Ferroptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress

1 reference

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22 May 2018

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

1 reference

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22 May 2018

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

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22 May 2018

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

1 reference

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22 May 2018

Necroptosis in health and diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

1 reference

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22 May 2018

Botch is a γ-glutamyl cyclotransferase that deglycinates and antagonizes Notch.

1 reference

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22 May 2018

Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients

1 reference

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22 May 2018

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

1 reference

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22 May 2018

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

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22 May 2018

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

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22 May 2018

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Glutathione synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Ferroptosis: an iron-dependent form of nonapoptotic cell death

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

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22 May 2018

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

1 reference

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22 May 2018

Automatic morphological subtyping reveals new roles of caspases in mitochondrial dynamics

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22 May 2018

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Triple-Negative Breast Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Triple-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Glutamine addiction: a new therapeutic target in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

Downregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

22 May 2018

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777716

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1 reference

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1 reference

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22 May 2018

CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade

1 reference

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22 May 2018

The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases

1 reference

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22 May 2018

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1 reference

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Importance of the trans-sulfuration pathway in cancer prevention and promotion.

1 reference

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22 May 2018

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

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22 May 2018

Biologic and pharmacologic regulation of mammalian glutathione synthesis

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14 August 2018

The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to l-asparaginase

1 reference

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12 December 2020

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Identifiers

10.18632/ONCOTARGET.23055

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13 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29383104%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29383104%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

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