(Q46213230)

20 December 2017

title

Metabolic targets for cancer therapy (English)

1 reference

20 December 2017

Erratum: Metabolic targets for cancer therapy

corrigendum / erratum

1 reference

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NRD4191

1

Lorenzo Galluzzi

1 reference

20 December 2017

Oliver Kepp

2

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Guido Kroemer

object named as

Guido Kroemer

series ordinal

4

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Matthew G Vander Heiden

series ordinal

3

object named as

Matthew G Vander Heiden

1 reference

20 December 2017

publication date

11 October 2013

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20 December 2017

Nature Reviews Drug Discovery

published in

1 reference

20 December 2017

volume

12

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20 December 2017

issue

11

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20 December 2017

page(s)

829-846

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20 December 2017

https://scigraph.springernature.com/pub.10.1038/nrd4145

exact match

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cites work

Otto Warburg's contributions to current concepts of cancer metabolism

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18F-FDG PET and PET/CT in the evaluation of cancer treatment response

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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How cancer metabolism is tuned for proliferation and vulnerable to disruption

31 March 2020

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Deconvoluting the context-dependent role for autophagy in cancer

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Hallmarks of Cancer: The Next Generation

31 March 2020

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Targeting cancer metabolism: a therapeutic window opens

31 March 2020

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Targeting metabolic transformation for cancer therapy.

31 March 2020

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Timeline: Chemotherapy and the war on cancer.

31 March 2020

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Molecular mechanisms of cancer development in obesity

31 March 2020

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The insulin and insulin-like growth factor receptor family in neoplasia: an update

31 March 2020

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Metformin and reduced risk of cancer in diabetic patients

31 March 2020

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Antidiabetic therapies affect risk of pancreatic cancer

31 March 2020

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Statin use and reduced cancer-related mortality

31 March 2020

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Statins and the risk of colorectal cancer

31 March 2020

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Phenformin as prophylaxis and therapy in breast cancer xenografts

31 March 2020

1 reference

Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens

31 March 2020

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LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

31 March 2020

1 reference

Metformin: mechanisms of antihyperglycemic action, other pharmacodynamic properties, and safety perspectives

31 March 2020

1 reference

Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism

31 March 2020

1 reference

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

31 March 2020

1 reference

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

31 March 2020

1 reference

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

31 March 2020

1 reference

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

31 March 2020

1 reference

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

31 March 2020

1 reference

Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells

31 March 2020

1 reference

Use of fibrates and cancer risk: a systematic review and meta-analysis of 17 long-term randomized placebo-controlled trials

31 March 2020

1 reference

Cancer metabolism: fatty acid oxidation in the limelight

31 March 2020

1 reference

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

31 March 2020

1 reference

The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer

31 March 2020

1 reference

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

31 March 2020

1 reference

Cancer research. Can fasting blunt chemotherapy's debilitating side effects?

31 March 2020

1 reference

Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival

31 March 2020

1 reference

Tumours with PI3K activation are resistant to dietary restriction

31 March 2020

1 reference

Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival

31 March 2020

1 reference

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

31 March 2020

1 reference

Aspirin and the risk of colorectal cancer in relation to the expression of COX-2.

31 March 2020

1 reference

Aspirin use and risk of colorectal cancer according to BRAF mutation status

31 March 2020

1 reference

The ancient drug salicylate directly activates AMP-activated protein kinase

31 March 2020

1 reference

Regulation of cancer cell metabolism

31 March 2020

1 reference

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

31 March 2020

1 reference

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

31 March 2020

1 reference

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

31 March 2020

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

1 reference

MYC-induced cancer cell energy metabolism and therapeutic opportunities

31 March 2020

1 reference

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

31 March 2020

1 reference

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

31 March 2020

1 reference

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

1 reference

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

31 March 2020

1 reference

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

31 March 2020

1 reference

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 March 2020

1 reference

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

31 March 2020

1 reference

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

31 March 2020

1 reference

Glut-1 translocation in FRTL-5 thyroid cells: role of phosphatidylinositol 3-kinase and N-glycosylation

31 March 2020

1 reference

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

31 March 2020

1 reference

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

31 March 2020

1 reference

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

31 March 2020

1 reference

The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway

31 March 2020

1 reference

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

31 March 2020

1 reference

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation

31 March 2020

1 reference

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

31 March 2020

1 reference

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

31 March 2020

1 reference

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

31 March 2020

1 reference

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

31 March 2020

1 reference

mTOR signaling in growth control and disease

31 March 2020

1 reference

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

31 March 2020

1 reference

Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation

31 March 2020

1 reference

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.

31 March 2020

1 reference

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

31 March 2020

1 reference

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

31 March 2020

1 reference

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

31 March 2020

1 reference

The diverse and complex roles of NF-κB subunits in cancer

31 March 2020

1 reference

p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

31 March 2020

1 reference

Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-κB-dependent GLUT3 expression

31 March 2020

1 reference

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

31 March 2020

1 reference

The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression

31 March 2020

1 reference

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

1 reference

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

31 March 2020

1 reference

p53 regulates mitochondrial respiration

31 March 2020

1 reference

Autophagy regulation by p53.

31 March 2020

1 reference

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

31 March 2020

1 reference

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

31 March 2020

1 reference

31 March 2020

1 reference

The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation

31 March 2020

1 reference

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

31 March 2020

1 reference

Hypoxia, HIF1 and glucose metabolism in the solid tumour

31 March 2020

1 reference

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

31 March 2020

1 reference

The functions and regulation of the PTEN tumour suppressor

31 March 2020

1 reference

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

31 March 2020

1 reference

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

31 March 2020

1 reference

Pten positively regulates brown adipose function, energy expenditure, and longevity

31 March 2020

1 reference

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

31 March 2020

1 reference

AMPK: a nutrient and energy sensor that maintains energy homeostasis

31 March 2020

1 reference

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

31 March 2020

1 reference

mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

31 March 2020

1 reference

Targeting hypoxia in cancer therapy

31 March 2020

1 reference

Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy

31 March 2020

1 reference

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

31 March 2020

1 reference

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

31 March 2020

1 reference

Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

31 March 2020

1 reference

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

31 March 2020

1 reference

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

31 March 2020

1 reference

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

31 March 2020

1 reference

Human SIRT6 promotes DNA end resection through CtIP deacetylation

31 March 2020

1 reference

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

1 reference

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.

31 March 2020

1 reference

Survivin, cancer networks and pathway-directed drug discovery.

31 March 2020

1 reference

Sirtuins as regulators of metabolism and healthspan

31 March 2020

1 reference

Sirtuins: critical regulators at the crossroads between cancer and aging

31 March 2020

1 reference

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

31 March 2020

1 reference

SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

31 March 2020

1 reference

Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis

31 March 2020

1 reference

Loss of the tumor suppressor PML in human cancers of multiple histologic origins

31 March 2020

1 reference

A metabolic prosurvival role for PML in breast cancer.

31 March 2020

1 reference

PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation

31 March 2020

1 reference

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

31 March 2020

1 reference

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

31 March 2020

1 reference

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

31 March 2020

1 reference

Mitochondrial tumour suppressors: a genetic and biochemical update

31 March 2020

1 reference

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

31 March 2020

1 reference

SDH mutations establish a hypermethylator phenotype in paraganglioma.

31 March 2020

1 reference

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

31 March 2020

1 reference

IDH1 and IDH2 mutations in gliomas

31 March 2020

1 reference

IDH mutations in glioma and acute myeloid leukemia

31 March 2020

1 reference

IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives

31 March 2020

1 reference

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

31 March 2020

1 reference

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

31 March 2020

1 reference

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

31 March 2020

1 reference

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

31 March 2020

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

31 March 2020

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

31 March 2020

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

1 reference

IDH mutation impairs histone demethylation and results in a block to cell differentiation

31 March 2020

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

31 March 2020

1 reference

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

31 March 2020

1 reference

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

31 March 2020

1 reference

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

31 March 2020

1 reference

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

31 March 2020

1 reference

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

31 March 2020

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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

31 March 2020

1 reference

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

31 March 2020

1 reference

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

31 March 2020

1 reference

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

31 March 2020

1 reference

Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects.

31 March 2020

1 reference

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

31 March 2020

1 reference

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

31 March 2020

1 reference

The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model.

31 March 2020

1 reference

Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells

31 March 2020

1 reference

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

31 March 2020

1 reference

3-Bromopyruvate: targets and outcomes

31 March 2020

1 reference

Targeting glucose metabolism for cancer therapy

31 March 2020

1 reference

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

31 March 2020

1 reference

Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

31 March 2020

1 reference

Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer

31 March 2020

1 reference

Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells

31 March 2020

1 reference

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

31 March 2020

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

31 March 2020

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

1 reference

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

31 March 2020

1 reference

A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.

31 March 2020

1 reference

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

31 March 2020

1 reference

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

31 March 2020

1 reference

In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147

31 March 2020

1 reference

Role of PFKFB3-driven glycolysis in vessel sprouting

31 March 2020

1 reference

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

31 March 2020

1 reference

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

31 March 2020

1 reference

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

31 March 2020

1 reference

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

31 March 2020

1 reference

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

31 March 2020

1 reference

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

31 March 2020

1 reference

Acidity generated by the tumor microenvironment drives local invasion

31 March 2020

1 reference

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

31 March 2020

1 reference

Metabolic modulation of glioblastoma with dichloroacetate

31 March 2020

1 reference

Case report: Sodium dichloroacetate (DCA) inhibition of the "Warburg Effect" in a human cancer patient: complete response in non-Hodgkin's lymphoma after disease progression with rituximab-CHOP.

31 March 2020

1 reference

Interfering with pH regulation in tumours as a therapeutic strategy

31 March 2020

1 reference

A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell

31 March 2020

1 reference

Phase II study of E7070 in patients with metastatic melanoma

31 March 2020

1 reference

A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer

31 March 2020

1 reference

31 March 2020

Mitochondria and cancer

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Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.

31 March 2020

1 reference

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

31 March 2020

1 reference

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

1 reference

Glutamine addiction: a new therapeutic target in cancer

31 March 2020

1 reference

Targeting mitochondria for cancer therapy

31 March 2020

1 reference

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

31 March 2020

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

31 March 2020

1 reference

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

31 March 2020

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

31 March 2020

1 reference

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

31 March 2020

1 reference

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

31 March 2020

1 reference

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

31 March 2020

1 reference

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

31 March 2020

1 reference

Survival after treatment with phenylacetate and benzoate for urea-cycle disorders

31 March 2020

1 reference

Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.

31 March 2020

1 reference

Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors

31 March 2020

1 reference

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells.

31 March 2020

1 reference

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

31 March 2020

1 reference

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

31 March 2020

1 reference

A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation

31 March 2020

1 reference

The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

31 March 2020

1 reference

Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.

31 March 2020

1 reference

The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice

31 March 2020

1 reference

Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice

31 March 2020

1 reference

Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivo

31 March 2020

1 reference

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

31 March 2020

1 reference

G6PD deficiency: global distribution, genetic variants and primaquine therapy

31 March 2020

1 reference

Glucose-6-phosphate dehydrogenase deficiency and cancer in a Sardinian male population: a case-control study

31 March 2020

1 reference

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

31 March 2020

1 reference

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

31 March 2020

1 reference

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

31 March 2020

1 reference

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

1 reference

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

31 March 2020

1 reference

Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and

31 March 2020

1 reference

THE EFFECT OF ARGINASE ON THE RETARDATION OF TUMOUR GROWTH.

31 March 2020

1 reference

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

31 March 2020

1 reference

Use of ?-asparaginase in childhood ALL

31 March 2020

1 reference

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

31 March 2020

1 reference

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

31 March 2020

1 reference

mTOR and cancer: insights into a complex relationship

31 March 2020

1 reference

Rapamycin passes the torch: a new generation of mTOR inhibitors

31 March 2020

1 reference

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

31 March 2020

1 reference

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

31 March 2020

1 reference

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

31 March 2020

1 reference

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

31 March 2020

1 reference

ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

31 March 2020

1 reference

A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling

31 March 2020

1 reference

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

31 March 2020

1 reference

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

31 March 2020

1 reference

MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase

31 March 2020

1 reference

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

31 March 2020

1 reference

Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth

31 March 2020

1 reference

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

31 March 2020

1 reference

Nicotinamide phosphoribosyltransferase: a potent therapeutic target in non-small cell lung cancer with epidermal growth factor receptor-gene mutation.

31 March 2020

1 reference

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

31 March 2020

1 reference

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

31 March 2020

1 reference

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

31 March 2020

1 reference

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

31 March 2020

1 reference

Autophagy and cellular immune responses

31 March 2020

1 reference

A two-way street: reciprocal regulation of metabolism and signalling.

31 March 2020

1 reference

Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

1 reference

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

31 March 2020

1 reference

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

31 March 2020

1 reference

Non-cell-autonomous tumor suppression by p53.

31 March 2020

1 reference

Metabolic flux and the regulation of mammalian cell growth

31 March 2020

1 reference

Mitochondria: master regulators of danger signalling

31 March 2020

1 reference

Non-apoptotic functions of apoptosis-regulatory proteins

31 March 2020

1 reference

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

31 March 2020

1 reference

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

31 March 2020

1 reference

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

31 March 2020

1 reference

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

31 March 2020

1 reference

Metabolism and proliferation share common regulatory pathways in cancer cells

31 March 2020

1 reference

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

31 March 2020

1 reference

Cancer metabolism: current perspectives and future directions

31 March 2020

1 reference

The metabolic life and times of a T-cell

31 March 2020

1 reference

Normal and cancer cell metabolism: lymphocytes and lymphoma.

31 March 2020

1 reference

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

31 March 2020

1 reference

Hallmarks of cancer: interactions with the tumor stroma.

31 March 2020

1 reference

Myeloid-Derived Suppressor Cells in Human Cancer

31 March 2020

1 reference

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

31 March 2020

1 reference

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

31 March 2020

1 reference

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

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Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.

31 March 2020

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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

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Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

31 March 2020

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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

31 March 2020

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Identification of small molecule inhibitors of pyruvate kinase M2

31 March 2020

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A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule

31 March 2020

1 reference

12 December 2020

Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts

1 reference

12 December 2020

Loss of PTEN facilitates HIF-1-mediated gene expression

1 reference

12 December 2020

Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease

1 reference

12 December 2020

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

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12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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12 December 2020

Glucose-6-phosphate dehydrogenase deficiency and lung cancer: a hospital based case-control study

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12 December 2020

Identifiers

DOI

10.1038/NRD4145

1 reference

20 December 2017

Dimensions Publication ID

1015392659

0 references

1 reference

20 December 2017